Seroatlas · Human Serome Atlas

TRAPPC6B

Trafficking protein particle complex subunit 6B

Also known as: TPC6B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86SZ2
Gene
TRAPPC6B
Ensembl
ENSG00000182400
Chromosome
14
Canonical length
158 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport (Kummel et al., 2005 [PubMed 16025134]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>Q86SZ2|TRAPPC6B
     1  MADEALFLLL HNEMVSGVYK SAEQGEVENG RCITKLENMG FRVGQGLIER FTKDTARFKD
    61  ELDIMKFICK DFWTTVFKKQ IDNLRTNHQG IYVLQDNKFR LLTQMSAGKQ YLEHASKYLA
   121  FTCGLIRGGL SNLGIKSIVT AEVSSMPACK FQVMIQKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 35 nTPM
  • cerebral cortex: 27 nTPM
  • liver: 23 nTPM
  • retina: 23 nTPM
  • basal ganglia: 21 nTPM
  • hippocampal formation: 19 nTPM

Single-cell type

  • esophageal apical cells: 136 nCPM
  • sertoli cells: 116 nCPM
  • choroid plexus epithelial cells: 104 nCPM
  • distal convoluted tubule cells: 81 nCPM
  • cardiomyocytes: 79 nCPM
  • renal collecting duct intercalated cells: 78 nCPM

Immune cell

  • basophil: 9 nTPM
  • NK-cell: 7.7 nTPM
  • non-classical monocyte: 7.1 nTPM
  • intermediate monocyte: 6.8 nTPM
  • eosinophil: 5.6 nTPM
  • myeloid DC: 4.8 nTPM

Brain region

  • cerebral cortex: 37 nTPM
  • hippocampal formation: 32 nTPM
  • cerebellum: 30 nTPM
  • basal ganglia: 30 nTPM
  • hypothalamus: 27 nTPM
  • pons: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAPPC6B.

Disease | AllUniProt

Conditions TRAPPC6B is implicated in, by any mechanism.

  • Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy (NEDMEBA) MIM:617862

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 81 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.32
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC6B as an antibody target. Whether an autoantibody or antibody against TRAPPC6B could matter depends on whether native TRAPPC6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC6B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAPPC6B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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