Seroatlas · Human Serome Atlas

TRAPPC5

Trafficking protein particle complex subunit 5

Also known as: MGC52424, TPPC5_HUMAN, TRS31

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUR0
Gene: TRAPPC5
Ensembl: ENSG00000181029
Chromosome: 19
Canonical length: 188 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q8IUR0|TRAPPC5
     1  MEARFTRGKS ALLERALARP RTEVSLSAFA LLFSELVQHC QSRVFSVAEL QSRLAALGRQ
    61  VGARVLDALV AREKGARRET KVLGALLFVK GAVWKALFGK EADKLEQAND DARTFYIIER
   121  EPLINTYISV PKENSTLNCA SFTAGIVEAV LTHSGFPAKV TAHWHKGTTL MIKFEEAVIA
   181  RDRALEGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 175 nTPM

Expression across tissuesHPA

Tissue

testis: 175 nTPM
skeletal muscle: 110 nTPM
heart muscle: 101 nTPM
basal ganglia: 100 nTPM
amygdala: 100 nTPM
hippocampal formation: 98 nTPM

Single-cell type

late spermatids: 53 nCPM
other brain neurons: 42 nCPM
brain excitatory neurons: 32 nCPM
oligodendrocytes: 30 nCPM
brain inhibitory neurons: 30 nCPM
colonocytes: 25 nCPM

Immune cell

neutrophil: 531 nTPM
myeloid DC: 446 nTPM
intermediate monocyte: 397 nTPM
classical monocyte: 386 nTPM
non-classical monocyte: 368 nTPM
total PBMC: 336 nTPM

Brain region

hypothalamus: 92 nTPM
pons: 84 nTPM
cerebral cortex: 81 nTPM
midbrain: 80 nTPM
hippocampal formation: 79 nTPM
basal ganglia: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0.23
gnomAD missense Z: 2.4
DepMap mean gene effect: -0.72
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transport protein particle (TRAPP) component
NO signalling/Golgi transport ligand-binding domain superfamily
Transport protein particle (TRAPP) component
TRAPP I complex, subunit 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC5 as an antibody target. Whether an autoantibody or antibody against TRAPPC5 could matter depends on whether native TRAPPC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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