CLIC2

Protein identityUniProt · HPA

UniProt accession

O15247

Gene

CLIC2

Ensembl

ENSG00000155962

Chromosome

X

Canonical length

247 aa

Protein class

Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>O15247|CLIC2
     1  MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE
    61  LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF
   121  SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT
   181  LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA
   241  NVAKQKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLIC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

47 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.09

gnomAD pLI

0.05

gnomAD missense Z

1.27

DepMap mean gene effect

0.16

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chloride transport
• regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
• regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
• signal transduction

Molecular functions

• chloride channel activity
• glutathione peroxidase activity

Cellular components

• chloride channel complex
• cytoplasm
• cytosol
• membrane
• nucleoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Intracellular chloride channel
• Glutathione S-transferase, C-terminal-like
• Thioredoxin-like superfamily
• Glutathione S-transferase, C-terminal domain superfamily
• Glutathione transferase family
• CLIC, N-terminal domain
• Glutathione S-transferase, C-terminal domain
• CLIC-like N-terminal domain
• Chloride intracellular channel protein 2, C-terminal domain

KeywordsUniProt

• Chloride
• Chloride channel
• Cytoplasm
• Disulfide bond
• Ion channel
• Ion transport
• Membrane
• Oxidoreductase
• Transmembrane
• Transmembrane helix
• Transport
• Voltage-gated channel

InteractionsUniProt · HPA

Protein binding partners of CLIC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RYR2
• TRAPPC2