Seroatlas · Human Serome Atlas

TRAPPC13

Trafficking protein particle complex subunit 13

Also known as: C5orf44, FLJ13611, MGC48585, TPC13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A5PLN9
Gene
TRAPPC13
Ensembl
ENSG00000113597
Chromosome
5
Canonical length
417 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; vesicle coating; and vesicle tethering. Predicted to be located in cytosol. Predicted to be part of TRAPPIII protein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>A5PLN9|TRAPPC13
     1  MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP STVNGAEVLM
    61  LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA
   121  ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN
   181  AESDLSSVTD EVFLEAQIQN MTTSPMFMEK VSLEPSIMYN VTELNSVSQA GECVSTFGSR
   241  AYLQPMDTRQ YLYCLKPKNE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA
   301  PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSERTMDLV LEMCNTNSIH WCGISGRQLG
   361  KLHPSSSLCL ALTLLSSVQG LQSISGLRLT DTFLKRTYEY DDIAQVCVVS SAIKVES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 21 nTPM
  • kidney: 19 nTPM
  • prostate: 18 nTPM
  • thyroid gland: 16 nTPM
  • heart muscle: 16 nTPM
  • tongue: 16 nTPM

Single-cell type

  • sertoli cells: 87 nCPM
  • myonuclei: 78 nCPM
  • oligodendrocytes: 75 nCPM
  • lactotrophs: 70 nCPM
  • corticotrophs: 69 nCPM
  • somatotrophs: 68 nCPM

Immune cell

  • basophil: 18 nTPM
  • non-classical monocyte: 13 nTPM
  • MAIT T-cell: 11 nTPM
  • T-reg: 9.4 nTPM
  • intermediate monocyte: 9.3 nTPM
  • total PBMC: 9.1 nTPM

Brain region

  • white matter: 15 nTPM
  • hypothalamus: 12 nTPM
  • spinal cord: 12 nTPM
  • cerebellum: 12 nTPM
  • midbrain: 11 nTPM
  • pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
1.8
DepMap mean gene effect
-0.36
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Trafficking protein particle complex subunit 13
  • Trafficking protein particle complex subunit 13, N-terminal
  • Trafficking protein particle complex subunit 13, C-terminal
  • Trafficking protein particle complex subunit 13, middle domain
  • Trafficking protein particle complex subunit 13, N-terminal
  • Trafficking protein particle complex subunit 13, C-terminal
  • Trafficking protein particle complex subunit 13, middle domain

InteractionsUniProt · HPA

Protein binding partners of TRAPPC13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC13 as an antibody target. Whether an autoantibody or antibody against TRAPPC13 could matter depends on whether native TRAPPC13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAPPC13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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