Seroatlas · Human Serome Atlas

TRAPPC10

Trafficking protein particle complex subunit 10

Also known as: EHOC-1, TMEM1, TPC10_HUMAN, TRS130

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48553
Gene: TRAPPC10
Ensembl: ENSG00000160218
Chromosome: 21
Canonical length: 1259 aa
Protein class: Disease related genes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1259 residues, UniProt reviewed canonical sequence.

>P48553|TRAPPC10
     1  MDASEEPLPP VIYTMENKPI VTCAGDQNLF TSVYPTLSQQ LPREPMEWRR SYGRAPKMIH
    61  LESNFVQFKE ELLPKEGNKA LLTFPFLHIY WTECCDTEVY KATVKDDLTK WQNVLKAHSS
   121  VDWLIVIVEN DAKKKNKTNI LPRTSIVDKI RNDFCNKQSD RCVVLSDPLK DSSRTQESWN
   181  AFLTKLRTLL LMSFTKNLGK FEDDMRTLRE KRTEPGWSFC EYFMVQEELA FVFEMLQQFE
   241  DALVQYDELD ALFSQYVVNF GAGDGANWLT FFCQPVKSWN GLILRKPIDM EKRESIQRRE
   301  ATLLDLRSYL FSRQCTLLLF LQRPWEVAQR ALELLHNCVQ ELKLLEVSVP PGALDCWVFL
   361  SCLEVLQRIE GCCDRAQIDS NIAHTVGLWS YATEKLKSLG YLCGLVSEKG PNSEDLNRTV
   421  DLLAGLGAER PETANTAQSP YKKLKEALSS VEAFEKHYLD LSHATIEMYT SIGRIRSAKF
   481  VGKDLAEFYM RKKAPQKAEI YLQGALKNYL AEGWALPITH TRKQLAECQK HLGQIENYLQ
   541  TSSLLASDHH LTEEERKHFC QEILDFASQP SDSPGHKIVL PMHSFAQLRD LHFDPSNAVV
   601  HVGGVLCVEI TMYSQMPVPV HVEQIVVNVH FSIEKNSYRK TAEWLTKHKT SNGIINFPPE
   661  TAPFPVSQNS LPALELYEMF ERSPSDNSLN TTGIICRNVH MLLRRQESSS SLEMPSGVAL
   721  EEGAHVLRCS HVTLEPGANQ ITFRTQAKEP GTYTLRQLCA SVGSVWFVLP HIYPIVQYDV
   781  YSQEPQLHVE PLADSLLAGI PQRVKFTVTT GHYTIKNGDS LQLSNAEAML ILCQAESRAV
   841  VYSNTREQSS EAALRIQSSD KVTSISLPVA PAYHVIEFEL EVLSLPSAPA LGGESDMLGM
   901  AEPHRKHKDK QRTGRCMVTT DHKVSIDCPW SIYSTVIALT FSVPFRTTHS LLSSGTRKYV
   961  QVCVQNLSEL DFQLSDSYLV DTGDSTDLQL VPLNTQSQQP IYSKQSVFFV WELKWTEEPP
  1021  PSLHCRFSVG FSPASEEQLS ISLKPYTYEF KVENFFTLYN VKAEIFPPSG MEYCRTGSLC
  1081  SLEVLITRLS DLLEVDKDEA LTESDEHFST KLMYEVVDNS SNWAVCGKSC GVISMPVAAR
  1141  ATHRVHMEVM PLFAGYLPLP DVRLFKYLPH HSAHSSQLDA DSWIENDSLS VDKHGDDQPD
  1201  SSSLKSRGSV HSACSSEHKG LPMPRLQALP AGQVFNSSSG TQVLVIPSQD DHVLEVSVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 22 nTPM
lymph node: 20 nTPM
thymus: 19 nTPM
tonsil: 17 nTPM
spleen: 16 nTPM
rectum: 14 nTPM

Single-cell type

podocytes: 256 nCPM
nk-cells: 254 nCPM
neutrophil progenitors: 170 nCPM
neutrophils: 170 nCPM
oligodendrocytes: 169 nCPM
t-cells: 162 nCPM

Immune cell

basophil: 9.7 nTPM
MAIT T-cell: 2.4 nTPM
gdT-cell: 2 nTPM
NK-cell: 1.9 nTPM
memory CD8 T-cell: 1.6 nTPM
non-classical monocyte: 1.6 nTPM

Brain region

white matter: 35 nTPM
basal ganglia: 24 nTPM
pons: 23 nTPM
midbrain: 22 nTPM
cerebral cortex: 21 nTPM
thalamus: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAPPC10.

Disease | AllUniProt

Conditions TRAPPC10 is implicated in, by any mechanism.

Neurodevelopmental disorder with microcephaly, short stature, and speech delay (NEDMISS) MIM:620027

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 210 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with microcephaly, short stature, and speech delay
Intellectual disability
TRAPPopathy microcephalic
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, SHORT STATURE, SPEECH DELAY, AND BEHAVIORAL ABNORMALITIES

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 1.56
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

TRAPPC10/Trs130, C-terminal
Trafficking protein particle complex subunit TRAPPC10/Trs130
TRAPPC10/Trs130, N-terminal
TRAPPC10, Ig-like domain
Trafficking protein particle complex subunit 10, TRAPPC10
Trafficking protein particle complex subunit 10-like, N-terminal
TRAPPC10-like, immunoglobulin-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC10 as an antibody target. Whether an autoantibody or antibody against TRAPPC10 could matter depends on whether native TRAPPC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1.

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