Seroatlas · Human Serome Atlas

TRAPPC12

Trafficking protein particle complex subunit 12

Also known as: CGI-87, TPC12_HUMAN, TTC-15, TTC15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WVT3
Gene
TRAPPC12
Ensembl
ENSG00000171853
Chromosome
2
Canonical length
735 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to kinetochore; and regulation of kinetochore assembly. Located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; kinetochore; and perinuclear region of cytoplasm. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

735 residues, UniProt reviewed canonical sequence.

>Q8WVT3|TRAPPC12
     1  MEDAGGGEET PAPEAPHPPQ LAPPEEQGLL FQEETIDLGG DEFGSEENET ASEGSSPLAD
    61  KLNEHMMESV LISDSPNSEG DAGDLGRVRD EAEPGGEGDP GPEPAGTPSP SGEADGDCAP
   121  EDAAPSSGGA PRQDAAREVP GSEAARPEQE PPVAEPVPVC TIFSQRAPPA SGDGFEPQMV
   181  KSPSFGGASE ASARTPPQVV QPSPSLSTFF GDTAASHSLA SDFFDSFTTS AFISVSNPGA
   241  GSPAPASPPP LAVPGTEGRP EPVAMRGPQA AAPPASPEPF AHIQAVFAGS DDPFATALSM
   301  SEMDRRNDAW LPGEATRGVL RAVATQQRGA VFVDKENLTM PGLRFDNIQG DAVKDLMLRF
   361  LGEKAAAKRQ VLNADSVEQS FVGLKQLISC RNWRAAVDLC GRLLTAHGQG YGKSGLLTSH
   421  TTDSLQLWFV RLALLVKLGL FQNAEMEFEP FGNLDQPDLY YEYYPHVYPG RRGSMVPFSM
   481  RILHAELQQY LGNPQESLDR LHKVKTVCSK ILANLEQGLA EDGGMSSVTQ EGRQASIRLW
   541  RSRLGRVMYS MANCLLLMKD YVLAVEAYHS VIKYYPEQEP QLLSGIGRIS LQIGDIKTAE
   601  KYFQDVEKVT QKLDGLQGKI MVLMNSAFLH LGQNNFAEAH RFFTEILRMD PRNAVANNNA
   661  AVCLLYLGKL KDSLRQLEAM VQQDPRHYLH ESVLFNLTTM YELESSRSMQ KKQALLEAVA
   721  GKEGDSFNTQ CLKLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • testis: 94 nTPM
  • heart muscle: 46 nTPM
  • skeletal muscle: 45 nTPM
  • skin: 34 nTPM
  • basal ganglia: 30 nTPM
  • cerebellum: 27 nTPM

Single-cell type

  • late spermatids: 351 nCPM
  • late primary spermatocytes: 162 nCPM
  • early spermatids: 158 nCPM
  • renal collecting duct intercalated cells: 122 nCPM
  • microglia: 110 nCPM
  • renal connecting tubule cells: 110 nCPM

Immune cell

  • plasmacytoid DC: 4.3 nTPM
  • eosinophil: 3.8 nTPM
  • non-classical monocyte: 3.6 nTPM
  • intermediate monocyte: 2.5 nTPM
  • T-reg: 2.5 nTPM
  • memory CD8 T-cell: 2.2 nTPM

Brain region

  • pons: 38 nTPM
  • cerebral cortex: 37 nTPM
  • hypothalamus: 35 nTPM
  • medulla oblongata: 34 nTPM
  • white matter: 34 nTPM
  • cerebellum: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAPPC12.

Disease | AllUniProt

Conditions TRAPPC12 is implicated in, by any mechanism.

  • Encephalopathy, progressive, early-onset, with brain atrophy and spasticity (PEBAS) MIM:617669

Disease | GeneticClinVar

28 pathogenic / likely-pathogenic of 376 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
0.16
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC12 as an antibody target. Whether an autoantibody or antibody against TRAPPC12 could matter depends on whether native TRAPPC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAPPC12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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