Seroatlas · Human Serome Atlas

TRAPPC1

Trafficking protein particle complex subunit 1

Also known as: BET5, MUM2, TPPC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5R8
Gene: TRAPPC1
Ensembl: ENSG00000170043
Chromosome: 17
Canonical length: 145 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q9Y5R8|TRAPPC1
     1  MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS KMSPLDMKDG
    61  FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI YSALYVELVV KNPLCPLGQT
   121  VQSELFRSRL DSYVRSLPFF SARAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 160 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 160 nTPM
spleen: 159 nTPM
thymus: 155 nTPM
kidney: 153 nTPM
cerebral cortex: 151 nTPM
choroid plexus: 148 nTPM

Single-cell type

platelets: 491 nCPM
extravillous trophoblasts: 321 nCPM
megakaryocytes: 303 nCPM
migrating cytotrophoblasts: 255 nCPM
cytotrophoblasts: 230 nCPM
decidual stromal cells: 223 nCPM

Immune cell

eosinophil: 429 nTPM
basophil: 318 nTPM
total PBMC: 306 nTPM
plasmacytoid DC: 294 nTPM
T-reg: 290 nTPM
myeloid DC: 272 nTPM

Brain region

thalamus: 123 nTPM
hypothalamus: 106 nTPM
medulla oblongata: 100 nTPM
pons: 96 nTPM
midbrain: 95 nTPM
white matter: 95 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0.09
gnomAD missense Z: 1.28
DepMap mean gene effect: -1.17
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC1 as an antibody target. Whether an autoantibody or antibody against TRAPPC1 could matter depends on whether native TRAPPC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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