Seroatlas · Human Serome Atlas

CDYL

Chromodomain Y-like protein

Also known as: CDYL_HUMAN, CDYL1, DKFZP586C1622

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y232
Gene: CDYL
Ensembl: ENSG00000153046
Chromosome: 6
Canonical length: 598 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

598 residues, UniProt reviewed canonical sequence.

>Q9Y232|CDYL
     1  MTFQASHRSA WGKSRKKNWQ YEGPTQKLFL KRNNVSAPDG PSDPSISVSS EQSGAQQPPA
    61  LQVERIVDKR KNKKGKTEYL VRWKGYDSED DTWEPEQHLV NCEEYIHDFN RRHTEKQKES
   121  TLTRTNRTSP NNARKQISRS TNSNFSKTSP KALVIGKDHE SKNSQLFAAS QKFRKNTAPS
   181  LSSRKNMDLA KSGIKILVPK SPVKSRTAVD GFQSESPEKL DPVEQGQEDT VAPEVAAEKP
   241  VGALLGPGAE RARMGSRPRI HPLVPQVPGP VTAAMATGLA VNGKGTSPFM DALTANGTTN
   301  IQTSVTGVTA SKRKFIDDRR DQPFDKRLRF SVRQTESAYR YRDIVVRKQD GFTHILLSTK
   361  SSENNSLNPE VMREVQSALS TAAADDSKLV LLSAVGSVFC CGLDFIYFIR RLTDDRKRES
   421  TKMAEAIRNF VNTFIQFKKP IIVAVNGPAI GLGASILPLC DVVWANEKAW FQTPYTTFGQ
   481  SPDGCSTVMF PKIMGGASAN EMLLSGRKLT AQEACGKGLV SQVFWPGTFT QEVMVRIKEL
   541  ASCNPVVLEE SKALVRCNMK MELEQANERE CEVLKKIWGS AQGMDSMLKY LQRKIDEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDYL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 19 nTPM
placenta: 17 nTPM
skeletal muscle: 17 nTPM
esophagus: 16 nTPM
skin: 16 nTPM
urinary bladder: 15 nTPM

Single-cell type

endometrial glandular cells: 490 nCPM
pdcs: 447 nCPM
syncytiotrophoblasts: 435 nCPM
erythrocyte progenitors: 376 nCPM
urothelial cells: 290 nCPM
early spermatids: 276 nCPM

Immune cell

plasmacytoid DC: 6.8 nTPM
basophil: 5.4 nTPM
gdT-cell: 1.6 nTPM
myeloid DC: 1.6 nTPM
NK-cell: 1.6 nTPM
classical monocyte: 1.3 nTPM

Brain region

amygdala: 18 nTPM
thalamus: 18 nTPM
cerebral cortex: 18 nTPM
basal ganglia: 17 nTPM
medulla oblongata: 17 nTPM
white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 2.35
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

random inactivation of X chromosome
spermatid development
spermatogenesis
negative regulation of peptidyl-lysine crotonylation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDYL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDYL as an antibody target. Whether an autoantibody or antibody against CDYL could matter depends on whether native CDYL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDYL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDYL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...