Seroatlas · Human Serome Atlas

EZHIP

EZH inhibitory protein

Also known as: CATACOMB, CXorf67, EZHIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86X51
Gene: EZHIP
Ensembl: ENSG00000187690
Chromosome: X
Canonical length: 503 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables histone methyltransferase inhibitor activity. Involved in epigenetic regulation of gene expression. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>Q86X51|EZHIP
     1  MATQSDMEKE QKHQQDEGQG GLNNETALAS GDACGTGNQD PAASVTTVSS QASPSGGAAL
    61  SSSTAGSSAA AATSAAIFIT DEASGLPIIA AVLTERHSDR QDCRSPHEVF GCVVPEGGSQ
   121  AAVGPQKATG HADEHLAQTK SPGNSRRRKQ PCRNQAAPAQ KPPGRRLFPE PLPPSSPGFR
   181  PSSYPCSGAS TSSQATQPGP ALLSHASEAR PATRSRITLV ASALRRRASG PGPVIRGCTA
   241  QPGPAFPHRA THLDPARLSP ESAPGPARRG RASVPGPARR GCDSAPGPAR RGRDSAPVSA
   301  PRGRDSAPGS ARRGRDSAPG PALRVRTARS DAGHRSTSTT PGTGLRSRST QQRSALLSRR
   361  SLSGSADENP SCGTGSERLA FQSRSGSPDP EVPSRASPPV WHAVRMRASS PSPPGRFFLP
   421  IPQQWDESSS SSYASNSSSP SRSPGLSPSS PSPEFLGLRS ISTPSPESLR YALMPEFYAL
   481  SPVPPEEQAE IESTAHPATP PEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EZHIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.73
Highest tissue expression: 5.8 nTPM

Expression across tissuesHPA

Tissue

testis: 5.8 nTPM
cerebellum: 1.7 nTPM
pituitary gland: 0.9 nTPM
placenta: 0.9 nTPM
choroid plexus: 0.5 nTPM
spleen: 0.5 nTPM

Single-cell type

differentiating spermatogonia: 0.2 nCPM
early primary spermatocytes: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

memory B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 5 nTPM
basal ganglia: 3.5 nTPM
cerebellum: 3.1 nTPM
cerebral cortex: 3.1 nTPM
amygdala: 2.9 nTPM
choroid plexus: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

histone methyltransferase inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

EZH Inhibitory Protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EZHIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EZHIP as an antibody target. Whether an autoantibody or antibody against EZHIP could matter depends on whether native EZHIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EZHIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EZHIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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