Seroatlas · Human Serome Atlas

USPL1

SUMO-specific isopeptidase USPL1

Also known as: bA121O19.1, C13orf22, D13S106E, USPL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5W0Q7
Gene: USPL1
Ensembl: ENSG00000132952
Chromosome: 13
Canonical length: 1092 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Enables SUMO binding activity and deSUMOylase activity. Involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Located in Cajal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1092 residues, UniProt reviewed canonical sequence.

>Q5W0Q7|USPL1
     1  MMDSPKIGNG LPVIGPGTDI GISSLHMVGY LGKNFDSAKV PSDEYCPACR EKGKLKALKT
    61  YRISFQESIF LCEDLQCIYP LGSKSLNNLI SPDLEECHTP HKPQKRKSLE SSYKDSLLLA
   121  NSKKTRNYIA IDGGKVLNSK HNGEVYDETS SNLPDSSGQQ NPIRTADSLE RNEILEADTV
   181  DMATTKDPAT VDVSGTGRPS PQNEGCTSKL EMPLESKCTS FPQALCVQWK NAYALCWLDC
   241  ILSALVHSEE LKNTVTGLCS KEESIFWRLL TKYNQANTLL YTSQLSGVKD GDCKKLTSEI
   301  FAEIETCLNE VRDEIFISLQ PQLRCTLGDM ESPVFAFPLL LKLETHIEKL FLYSFSWDFE
   361  CSQCGHQYQN RHMKSLVTFT NVIPEWHPLN AAHFGPCNNC NSKSQIRKMV LEKVSPIFML
   421  HFVEGLPQND LQHYAFHFEG CLYQITSVIQ YRANNHFITW ILDADGSWLE CDDLKGPCSE
   481  RHKKFEVPAS EIHIVIWERK ISQVTDKEAA CLPLKKTNDQ HALSNEKPVS LTSCSVGDAA
   541  SAETASVTHP KDISVAPRTL SQDTAVTHGD HLLSGPKGLV DNILPLTLEE TIQKTASVSQ
   601  LNSEAFLLEN KPVAENTGIL KTNTLLSQES LMASSVSAPC NEKLIQDQFV DISFPSQVVN
   661  TNMQSVQLNT EDTVNTKSVN NTDATGLIQG VKSVEIEKDA QLKQFLTPKT EQLKPERVTS
   721  QVSNLKKKET TADSQTTTSK SLQNQSLKEN QKKPFVGSWV KGLISRGASF MPLCVSAHNR
   781  NTITDLQPSV KGVNNFGGFK TKGINQKASH VSKKARKSAS KPPPISKPPA GPPSSNGTAA
   841  HPHAHAASEV LEKSGSTSCG AQLNHSSYGN GISSANHEDL VEGQIHKLRL KLRKKLKAEK
   901  KKLAALMSSP QSRTVRSENL EQVPQDGSPN DCESIEDLLN ELPYPIDIAS ESACTTVPGV
   961  SLYSSQTHEE ILAELLSPTP VSTELSENGE GDFRYLGMGD SHIPPPVPSE FNDVSQNTHL
  1021  RQDHNYCSPT KKNPCEVQPD SLTNNACVRT LNLESPMKTD IFDEFFSSSA LNALANDTLD
  1081  LPHFDEYLFE NY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 23 nTPM
testis: 17 nTPM
spleen: 15 nTPM
retina: 14 nTPM
liver: 13 nTPM
lymph node: 12 nTPM

Single-cell type

late spermatids: 578 nCPM
early spermatids: 205 nCPM
cone photoreceptor cells: 201 nCPM
pancreatic duct cells: 163 nCPM
b-cells: 152 nCPM
retinal bipolar cells: 123 nCPM

Immune cell

naive B-cell: 5.7 nTPM
memory B-cell: 5.3 nTPM
MAIT T-cell: 5 nTPM
naive CD4 T-cell: 4.8 nTPM
NK-cell: 4.5 nTPM
naive CD8 T-cell: 4.3 nTPM

Brain region

cerebral cortex: 17 nTPM
white matter: 15 nTPM
cerebellum: 15 nTPM
hippocampal formation: 10 nTPM
basal ganglia: 10 nTPM
thalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.02
gnomAD missense Z: 0.43
DepMap mean gene effect: -1.21
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin specific protease UPS, catalytic domain
Papain-like cysteine peptidase superfamily
Ubiquitin-specific peptidase-like, SUMO isopeptidase
Domain of unknown function DUF4650
USPL1 peptidase
Ubiquitin-specific peptidase-like, SUMO isopeptidase
Domain of unknown function (DUF4650)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of USPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USPL1 as an antibody target. Whether an autoantibody or antibody against USPL1 could matter depends on whether native USPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USPL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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