Seroatlas · Human Serome Atlas

ZNF451

E3 SUMO-protein ligase ZNF451

Also known as: COASTER, dJ417I1.1, KIAA0576, KIAA1702, ZATT, ZN451_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4E5
Gene: ZNF451
Ensembl: ENSG00000112200
Chromosome: 6
Canonical length: 1061 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables SUMO ligase activity; transcription corepressor activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in PML body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1061 residues, UniProt reviewed canonical sequence.

>Q9Y4E5|ZNF451
     1  MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS SDDEEPSTSY
    61  TDENIKRKDH IDYQKDKVAL TLARLARHVE VEKQQKEEKN RAFREKIDFQ HAHGLQELEF
   121  IRGHSDTEAA RLCVDQWLKM PGLKTGTINC GTKSSFRRGG HTWVSGKPIL CPIMHCNKEF
   181  DNGHLLLGHL KRFDHSPCDP TITLHGPFFS SFACVVCYKK FVTQQQYRDH LFDKEATDDG
   241  HNNNLLPQII QCFACPNCFL LFSRKEECSK HMSGKNHFHQ SFKLGDNKGI AHPISFPSFA
   301  KKLLISLCKD VPFQVKCVAC HKTLRSHMEL TAHFRVHCRN AGPVAVAEKS ITQVAEKFIL
   361  RGYCPDCNQV FVDETSTQNH KQNSGHKVRV INSVEESVLL YCHSSEGNKD PSSDLHLLLD
   421  QSKFSSLKRT MSIKESSSLE CIAIPKKKMN LKDKSHEGVA CVQKEKSVVK TWFCECNQRF
   481  PSEDAVEKHV FSANTMGYKC VVCGKVCDDS GVIRLHMSRI HGGAHLNNFL FWCRTCKKEL
   541  TRKDTIMAHV TEFHNGHRYF YEMDEVEGET LPSSSTTLDN LTANKPSSAI TVIDHSPANS
   601  SPRGKWQCRI CEDMFDSQEY VKQHCMSLAS HKFHRYSCAH CRKPFHKIET LYRHCQDEHD
   661  NEIKIKYFCG LCDLIFNVEE AFLSHYEEHH SIDYVFVSEK TETSIKTEDD FPVIETSNQL
   721  TCGCRESYIC KVNRKEDYSR CLQIMLDKGK LWFRCSLCSA TAQNLTDMNT HIHQVHKEKS
   781  DEEEQQYVIK CGTCTKAFHD PESAQQHFHR KHCFLQKPSV AHFGSEKSNL YKFTASASHT
   841  ERKLKQAINY SKSLDMEKGV ENDLSYQNIE EEIVELPDLD YLRTMTHIVF VDFDNWSNFF
   901  GHLPGHLNQG TFIWGFQGGN TNWKPPLNCK IYNYLNRIGC FFLHPRCSKR KDAADFAICM
   961  HAGRLDEQLP KQIPFTILSG DQGFLELENQ FKKTQRPAHI LNPHHLEGDM MCALLNSISD
  1021  TTKECDSDDN MGAKNTSIGE EFISTEDVEL EEAIRRSLEE M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF451 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 66 nTPM
testis: 27 nTPM
retina: 16 nTPM
cerebellum: 16 nTPM
thymus: 15 nTPM
spinal cord: 15 nTPM

Single-cell type

late spermatids: 661 nCPM
adrenal cortex cells: 343 nCPM
early spermatids: 322 nCPM
oligodendrocytes: 238 nCPM
erythrocyte progenitors: 220 nCPM
lactotrophs: 186 nCPM

Immune cell

basophil: 34 nTPM
naive B-cell: 15 nTPM
plasmacytoid DC: 15 nTPM
naive CD4 T-cell: 12 nTPM
gdT-cell: 11 nTPM
MAIT T-cell: 11 nTPM

Brain region

cerebellum: 85 nTPM
white matter: 74 nTPM
basal ganglia: 61 nTPM
medulla oblongata: 55 nTPM
pons: 54 nTPM
thalamus: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
ZNF451, PIN-like domain
ZNF451, double C2H2 zinc finger domain
ZNF451, C-terminal C2H2 type zinc fingers
ZNF451, second C2H2 type zinc finger
ZNF451, sixth C2H2 type zinc finger
ZNF451, first C2H2 type zinc finger
ZNF451, fifth C2H2 type zinc finger
PIN like domain
First Zinc fingers C2H2 type, ZNF451
Second Zinc fingers C2H2 type, ZNF451
Fifth Zinc fingers C2H2 type, ZNF451
Sixth Zinc fingers C2H2 type, ZNF451
Two consecutive Zinc fingers C2H2 type, ZNF451
Two consecutive Zinc fingers C2H2 type, ZNF451

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF451 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF451 as an antibody target. Whether an autoantibody or antibody against ZNF451 could matter depends on whether native ZNF451 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF451 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF451 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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