Seroatlas · Human Serome Atlas

SLC7A1

High affinity cationic amino acid transporter 1

Also known as: ATRC1, CAT-1, CTR1_HUMAN, ERR, HCAT1, REC1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30825
Gene
SLC7A1
Ensembl
ENSG00000139514
Chromosome
13
Canonical length
629 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables L-arginine transmembrane transporter activity; L-histidine transmembrane transporter activity; and L-lysine transmembrane transporter activity. Involved in carboxylic acid transport. Located in apical plasma membrane and basolateral plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

629 residues, UniProt reviewed canonical sequence.

>P30825|SLC7A1
     1  MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV YVLAGAVARE
    61  NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS
   121  YIIGTSSVAR AWSATFDELI GRPIGEFSRT HMTLNAPGVL AENPDIFAVI IILILTGLLT
   181  LGVKESAMVN KIFTCINVLV LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG
   241  KPGVGGFMPF GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA
   301  YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS LLGSMFPMPR
   361  VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA FLFDLKDLVD LMSIGTLLAY
   421  SLVAACVLVL RYQPEQPNLV YQMASTSDEL DPADQNELAS TNDSQLGFLP EAEMFSLKTI
   481  LSPKNMEPSK ISGLIVNIST SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA
   541  VVTGVIWRQP ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY
   601  FGYGLWHSEE ASLDADQART PDGNLDQCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC7A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
14
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 52 nTPM
  • pancreas: 29 nTPM
  • cerebral cortex: 19 nTPM
  • skin: 17 nTPM
  • salivary gland: 15 nTPM
  • small intestine: 14 nTPM

Single-cell type

  • basal keratinocytes: 337 nCPM
  • esophageal basal cells: 308 nCPM
  • salivary myoepithelial cells: 270 nCPM
  • epididymal basal cells: 264 nCPM
  • endometrial glandular cells: 258 nCPM
  • salivary acinar cells: 243 nCPM

Immune cell

  • plasmacytoid DC: 1.2 nTPM
  • gdT-cell: 1 nTPM
  • non-classical monocyte: 1 nTPM
  • naive CD8 T-cell: 0.9 nTPM
  • MAIT T-cell: 0.8 nTPM
  • memory CD8 T-cell: 0.8 nTPM

Brain region

  • pons: 85 nTPM
  • thalamus: 83 nTPM
  • medulla oblongata: 78 nTPM
  • amygdala: 72 nTPM
  • spinal cord: 71 nTPM
  • hippocampal formation: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
3.3
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC7A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC7A1 as an antibody target. Whether an autoantibody or antibody against SLC7A1 could matter depends on whether native SLC7A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC7A1 is annotated at the cell surface, where native SLC7A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC7A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC7A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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