Seroatlas · Human Serome Atlas

STIMATE

Store-operated calcium entry regulator STIMATE

Also known as: MGC52022, STIMA_HUMAN, TMEM110

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86TL2
Gene
STIMATE
Ensembl
ENSG00000213533
Chromosome
3
Canonical length
294 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables calcium channel regulator activity. Involved in activation of store-operated calcium channel activity and store-operated calcium entry. Located in cortical endoplasmic reticulum; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>Q86TL2|STIMATE
     1  MQGPAGNASR GLPGGPPSTV ASGAGRCESG ALMHSFGIFL QGLLGVVAFS TLMLKRFREP
    61  KHERRPWRIW FLDTSKQAIG MLFIHFANVY LADLTEEDPC SLYLINFLLD ATVGMLLIYV
   121  GVRAVSVLVE WQQWESLRFG EYGDPLQCGA WVGQCALYIV IMIFEKSVVF IVLLILQWKK
   181  VALLNPIENP DLKLAIVMLI VPFFVNALMF WVVDNFLMRK GKTKAKLEER GANQDSRNGS
   241  KVRYRRAASH EESESEILIS ADDEMEESDV EEDLRRLTPL KPVKKKKHRF GLPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STIMATE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • liver: 30 nTPM
  • bone marrow: 22 nTPM
  • blood vessel: 22 nTPM
  • skeletal muscle: 16 nTPM
  • fallopian tube: 12 nTPM
  • pancreas: 11 nTPM

Single-cell type

  • microglia: 38 nCPM
  • bergmann glia: 30 nCPM
  • oligodendrocytes: 28 nCPM
  • astrocytes: 27 nCPM
  • oligodendrocyte progenitor cells: 25 nCPM
  • brain excitatory neurons: 23 nCPM

Immune cell

  • intermediate monocyte: 3.1 nTPM
  • non-classical monocyte: 2.9 nTPM
  • T-reg: 2.5 nTPM
  • myeloid DC: 2 nTPM
  • memory CD4 T-cell: 1.7 nTPM
  • classical monocyte: 1.6 nTPM

Brain region

  • cerebral cortex: 22 nTPM
  • medulla oblongata: 21 nTPM
  • amygdala: 20 nTPM
  • midbrain: 20 nTPM
  • basal ganglia: 20 nTPM
  • thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.19
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Store-operated calcium entry regulator STIMATE/YPL162C
  • STIMATE family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STIMATE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STIMATE as an antibody target. Whether an autoantibody or antibody against STIMATE could matter depends on whether native STIMATE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STIMATE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STIMATE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STIMATE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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