Seroatlas · Human Serome Atlas

STIM2

Stromal interaction molecule 2

Also known as: STIM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P246
Gene
STIM2
Ensembl
ENSG00000109689
Chromosome
4
Canonical length
746 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

746 residues, UniProt reviewed canonical sequence.

>Q9P246|STIM2
     1  MLVLGLLVAG AADGCELVPR HLRGRRATGS AATAASSPAA AAGDSPALMT DPCMSLSPPC
    61  FTEEDRFSLE ALQTIHKQMD DDKDGGIEVE ESDEFIREDM KYKDATNKHS HLHREDKHIT
   121  IEDLWKRWKT SEVHNWTLED TLQWLIEFVE LPQYEKNFRD NNVKGTTLPR IAVHEPSFMI
   181  SQLKISDRSH RQKLQLKALD VVLFGPLTRP PHNWMKDFIL TVSIVIGVGG CWFAYTQNKT
   241  SKEHVAKMMK DLESLQTAEQ SLMDLQERLE KAQEENRNVA VEKQNLERKM MDEINYAKEE
   301  ACRLRELREG AECELSRRQY AEQELEQVRM ALKKAEKEFE LRSSWSVPDA LQKWLQLTHE
   361  VEVQYYNIKR QNAEMQLAIA KDEAEKIKKK RSTVFGTLHV AHSSSLDEVD HKILEAKKAL
   421  SELTTCLRER LFRWQQIEKI CGFQIAHNSG LPSLTSSLYS DHSWVVMPRV SIPPYPIAGG
   481  VDDLDEDTPP IVSQFPGTMA KPPGSLARSS SLCRSRRSIV PSSPQPQRAQ LAPHAPHPSH
   541  PRHPHHPQHT PHSLPSPDPD ILSVSSCPAL YRNEEEEEAI YFSAEKQWEV PDTASECDSL
   601  NSSIGRKQSP PLSLEIYQTL SPRKISRDEV SLEDSSRGDS PVTVDVSWGS PDCVGLTETK
   661  SMIFSPASKV YNGILEKSCS MNQLSSGIPV PKPRHTSCSS AGNDSKPVQE APSVARISSI
   721  PHDLCHNGEK SKKPSKIKSL FKKKSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 59 nTPM
  • lymph node: 24 nTPM
  • tonsil: 22 nTPM
  • epididymis: 21 nTPM
  • spleen: 21 nTPM
  • thymus: 19 nTPM

Single-cell type

  • choroid plexus epithelial cells: 853 nCPM
  • renal connecting tubule cells: 362 nCPM
  • conjunctival goblet cells: 355 nCPM
  • retinal pigment epithelial cells: 311 nCPM
  • respiratory secretory cells: 288 nCPM
  • respiratory basal cells: 285 nCPM

Immune cell

  • basophil: 13 nTPM
  • non-classical monocyte: 6.5 nTPM
  • plasmacytoid DC: 5 nTPM
  • naive B-cell: 4.8 nTPM
  • naive CD4 T-cell: 4.5 nTPM
  • memory CD4 T-cell: 4.2 nTPM

Brain region

  • choroid plexus: 181 nTPM
  • hippocampal formation: 40 nTPM
  • basal ganglia: 32 nTPM
  • cerebral cortex: 32 nTPM
  • white matter: 32 nTPM
  • hypothalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
1.25
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STIM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STIM2 as an antibody target. Whether an autoantibody or antibody against STIM2 could matter depends on whether native STIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STIM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STIM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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