Seroatlas · Human Serome Atlas

SLC35G1

Solute carrier family 35 member G1

Also known as: C10orf60, FLJ33990, S35G1_HUMAN, TMEM20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M3R5
Gene: SLC35G1
Ensembl: ENSG00000176273
Chromosome: 10
Canonical length: 365 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a transmembrane protein which is a member of the drug/metabolite transporter protein superfamily. The encoded protein may play a role in the regulation of calcium levels inside the cell. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q2M3R5|SLC35G1
     1  MRPQDSTGVA ELQEPGLPLT DDAPPGATEE PAAAEAAGAP DRGRCWLCLS SPCCSRTEPE
    61  AKKKAPCPGL GLFYTLLSAF LFSVGSLFVK KVQDVHAVEI SAFRCVFQML VVIPCLIYRK
   121  TGFIGPKGQR IFLILRGVLG STAMMLIYYA YQTMSLADAT VITFSSPVFT SIFAWICLKE
   181  KYSPWDALFT VFTITGVILI VRPPFLFGSD TSGMEESYSG HLKGTFAAIG SAVFAASTLV
   241  ILRKMGKSVD YFLSIWYYVV LGLVESVIIL SVLGEWSLPY CGLDRLFLIF IGLFGLGGQI
   301  FITKALQIEK AGPVAIMKTM DVVFAFIFQI IFFNNVPTWW TVGGALCVVA SNVGAAIRKW
   361  YQSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35G1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

duodenum: 64 nTPM
small intestine: 32 nTPM
pancreas: 9 nTPM
colon: 5.7 nTPM
rectum: 5.5 nTPM
liver: 3.4 nTPM

Single-cell type

pituicytes/fscs: 63 nCPM
enterocytes: 59 nCPM
peritubular myoid cells: 58 nCPM
thyrotrophs: 44 nCPM
late primary spermatocytes: 41 nCPM
parietal cells: 41 nCPM

Immune cell

T-reg: 1.1 nTPM
memory CD4 T-cell: 0.8 nTPM
naive CD4 T-cell: 0.8 nTPM
eosinophil: 0.7 nTPM
memory CD8 T-cell: 0.5 nTPM
naive CD8 T-cell: 0.5 nTPM

Brain region

choroid plexus: 2.5 nTPM
pons: 1 nTPM
medulla oblongata: 0.8 nTPM
cerebellum: 0.7 nTPM
hypothalamus: 0.7 nTPM
midbrain: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.16
gnomAD missense Z: 0.01
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC35G1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35G1 as an antibody target. Whether an autoantibody or antibody against SLC35G1 could matter depends on whether native SLC35G1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35G1 is annotated at the cell surface, where native SLC35G1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC35G1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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