ORAI3
Protein orai-3
Also known as: MGC13024, ORAI3_HUMAN, TMEM142C
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BRQ5
- Gene
- ORAI3
- Ensembl
- ENSG00000175938
- Chromosome
- 16
- Canonical length
- 295 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables store-operated calcium channel activity. Involved in store-operated calcium entry. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
295 residues, UniProt reviewed canonical sequence.
>Q9BRQ5|ORAI3
1 MKGGEGDAGE QAPLNPEGES PAGSATYREF VHRGYLDLMG ASQHSLRALS WRRLYLSRAK
61 LKASSRTSAL LSGFAMVAMV EVQLESDHEY PPGLLVAFSA CTTVLVAVHL FALMVSTCLL
121 PHIEAVSNIH NLNSVHQSPH QRLHRYVELA WGFSTALGTF LFLAEVVLVG WVKFVPIGAP
181 LDTPTPMVPT SRVPGTLAPV ATSLSPASNL PRSSASAAPS QAEPACPPRQ ACGGGGAHGP
241 GWQAAMASTA IMVPVGLVFV AFALHFYRSL VAHKTDRYKQ ELEELNRLQG ELQAVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ORAI3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 68 nTPM
Expression across tissuesHPA
Tissue
- liver: 68 nTPM
- choroid plexus: 39 nTPM
- adrenal gland: 33 nTPM
- urinary bladder: 28 nTPM
- prostate: 25 nTPM
- cervix: 23 nTPM
Single-cell type
- hofbauer cells: 8.8 nCPM
- podocytes: 8.5 nCPM
- papillary tip epithelial cells: 6.7 nCPM
- megakaryocytes: 6.2 nCPM
- respiratory ionocytes: 5.1 nCPM
- proximal tubule cells: 4.8 nCPM
Immune cell
- eosinophil: 27 nTPM
- basophil: 23 nTPM
- neutrophil: 15 nTPM
- non-classical monocyte: 13 nTPM
- NK-cell: 12 nTPM
- plasmacytoid DC: 9.5 nTPM
Brain region
- choroid plexus: 36 nTPM
- thalamus: 25 nTPM
- medulla oblongata: 20 nTPM
- midbrain: 20 nTPM
- amygdala: 19 nTPM
- white matter: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.23
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 0.07
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ORAI3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ORAI3 as an antibody target. Whether an autoantibody or antibody against ORAI3 could matter depends on whether native ORAI3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ORAI3 is annotated at the cell surface, where native ORAI3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label ORAI3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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