TMEM178A
Transmembrane protein 178A
Also known as: MGC33926, T178A_HUMAN, TMEM178
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NBL3
- Gene
- TMEM178A
- Ensembl
- ENSG00000152154
- Chromosome
- 2
- Canonical length
- 297 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Predicted to be involved in negative regulation of osteoclast differentiation and regulation of cytosolic calcium ion concentration. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
297 residues, UniProt reviewed canonical sequence.
>Q8NBL3|TMEM178A
1 MEPRALVTAL SLGLSLCSLG LLVTAIFTDH WYETDPRRHK ESCERSRAGA DPPDQKNRLM
61 PLSHLPLRDS PPLGRRLLPG GPGRADPESW RSLLGLGGLD AECGRPLFAT YSGLWRKCYF
121 LGIDRDIDTL ILKGIAQRCT AIKYHFSQPI RLRNIPFNLT KTIQQDEWHL LHLRRITAGF
181 LGMAVAVLLC GCIVATVSFF WEESLTQHVA GLLFLMTGIF CTISLCTYAA SISYDLNRLP
241 KLIYSLPADV EHGYSWSIFC AWCSLGFIVA AGGLCIAYPF ISRTKIAQLK SGRDSTVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM178A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 3
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 381 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 381 nTPM
- spinal cord: 114 nTPM
- cerebral cortex: 82 nTPM
- hippocampal formation: 71 nTPM
- amygdala: 54 nTPM
- midbrain: 43 nTPM
Single-cell type
- brain excitatory neurons: 210 nCPM
- renal connecting tubule cells: 198 nCPM
- retinal amacrine cells: 179 nCPM
- podocytes: 161 nCPM
- breast myoepithelial cells: 95 nCPM
- brain inhibitory neurons: 86 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 209 nTPM
- white matter: 151 nTPM
- hippocampal formation: 77 nTPM
- cerebral cortex: 75 nTPM
- pons: 65 nTPM
- spinal cord: 65 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.51
- gnomAD pLI
- 0.67
- gnomAD missense Z
- 1.79
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TMEM178A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM178A as an antibody target. Whether an autoantibody or antibody against TMEM178A could matter depends on whether native TMEM178A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM178A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM178A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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