Seroatlas · Human Serome Atlas

ORAI2

Protein orai-2

Also known as: C7orf19, CBCIP2, FLJ12474, FLJ14733, H_NH0514P08.8, ORAI2_HUMAN, TMEM142B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SN7
Gene: ORAI2
Ensembl: ENSG00000160991
Chromosome: 7
Canonical length: 254 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

Enables store-operated calcium channel activity. Involved in store-operated calcium entry. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q96SN7|ORAI2
     1  MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW RKLYLSRAKL
    61  KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC TTVLVAVHLF ALLISTCILP
   121  NVEAVSNIHN LNSISESPHE RMHPYIELAW GFSTVLGILL FLAEVVLLCW IKFLPVDARR
   181  QPGPPPGPGS HTGWQAALVS TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL
   241  KVQLDGHERS LQVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ORAI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 15 nTPM
pituitary gland: 14 nTPM
parathyroid gland: 12 nTPM
spleen: 11 nTPM
appendix: 11 nTPM
cerebellum: 11 nTPM

Single-cell type

platelets: 340 nCPM
neutrophils: 290 nCPM
neutrophil progenitors: 241 nCPM
endometrial luminal cells: 159 nCPM
b-cells: 133 nCPM
lactotrophs: 91 nCPM

Immune cell

neutrophil: 28 nTPM
eosinophil: 25 nTPM
naive B-cell: 11 nTPM
memory B-cell: 10 nTPM
NK-cell: 8.3 nTPM
basophil: 7 nTPM

Brain region

hippocampal formation: 31 nTPM
cerebellum: 31 nTPM
thalamus: 30 nTPM
hypothalamus: 30 nTPM
pons: 29 nTPM
cerebral cortex: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0.2
gnomAD missense Z: 1.45
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

store-operated calcium entry

Molecular functions

store-operated calcium channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ORAI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ORAI2 as an antibody target. Whether an autoantibody or antibody against ORAI2 could matter depends on whether native ORAI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ORAI2 is annotated at the cell surface, where native ORAI2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ORAI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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