Seroatlas · Human Serome Atlas

ORAI1

Calcium release-activated calcium channel protein 1

Also known as: CRACM1, FLJ14466, ORAI1_HUMAN, TMEM142A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96D31
Gene
ORAI1
Ensembl
ENSG00000276045
Chromosome
12
Canonical length
301 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>Q96D31|ORAI1
     1  MHPEPAPPPS RSSPELPPSG GSTTSGSRRS RRRSGDGEPP GAPPPPPSAV TYPDWIGQSY
    61  SEVMSLNEHS MQALSWRKLY LSRAKLKASS RTSALLSGFA MVAMVEVQLD ADHDYPPGLL
   121  IAFSACTTVL VAVHLFALMI STCILPNIEA VSNVHNLNSV KESPHERMHR HIELAWAFST
   181  VIGTLLFLAE VVLLCWVKFL PLKKQPGQPR PTSKPPASGA AANVSTSGIT PGQAAAIAST
   241  TIMVPFGLIF IVFAVHFYRS LVSHKTDRQF QELNELAEFA RLQDQLDHRG DHPLTPGSHY
   301  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ORAI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 63 nTPM
  • skeletal muscle: 57 nTPM
  • skin: 43 nTPM
  • spleen: 23 nTPM
  • duodenum: 20 nTPM
  • lung: 15 nTPM

Single-cell type

  • choroid plexus epithelial cells: 10 nCPM
  • microglia: 6.4 nCPM
  • oligodendrocyte progenitor cells: 5.9 nCPM
  • renal collecting duct intercalated cells: 5.8 nCPM
  • papillary tip epithelial cells: 4.2 nCPM
  • renal collecting duct principal cells: 3.7 nCPM

Immune cell

  • memory CD8 T-cell: 19 nTPM
  • gdT-cell: 19 nTPM
  • memory CD4 T-cell: 16 nTPM
  • naive CD4 T-cell: 15 nTPM
  • MAIT T-cell: 15 nTPM
  • T-reg: 14 nTPM

Brain region

  • choroid plexus: 42 nTPM
  • pons: 6.7 nTPM
  • medulla oblongata: 6.4 nTPM
  • spinal cord: 6.1 nTPM
  • cerebellum: 5.8 nTPM
  • thalamus: 5.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ORAI1.

Disease | AllUniProt

Conditions ORAI1 is implicated in, by any mechanism.

Disease | GeneticClinVar

22 pathogenic / likely-pathogenic of 469 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0
gnomAD missense Z
0.62

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ORAI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ORAI1 as an antibody target. Whether an autoantibody or antibody against ORAI1 could matter depends on whether native ORAI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ORAI1 is annotated at the cell surface, where native ORAI1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ORAI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ORAI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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