Seroatlas · Human Serome Atlas

SRSP

Splicing regulatory small protein

Also known as: SRSP_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DXC1
Gene: SRSP
Canonical length: 130 aa

OverviewNCBI Gene

No narrative summary is available for SRSP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>P0DXC1|SRSP
     1  MRTKPQRPRA TRSYLGQPCG SPRRTEETGE TWERVAFSLF THTCTQPLAG TVDTHLPSLL
    61  LPVILHPLGA ASAGRALEPK ADPHTCPYGR KESRGEKVRR GRAKSNSGPN VPGPPAAPQS
   121  LKSGSPSTRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72

OntologyGO

Biological processes

Molecular functions

pre-mRNA binding

Cellular components

nucleus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SRSF3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSP as an antibody target. Whether an autoantibody or antibody against SRSP could matter depends on whether native SRSP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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