Seroatlas · Human Serome Atlas

CEP76

Centrosomal protein of 76 kDa

Also known as: C18orf9, CEP76_HUMAN, FLJ12542, HsT1705

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAP6
Gene: CEP76
Ensembl: ENSG00000101624
Chromosome: 18
Canonical length: 659 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Microtubules,Mitotic spindle,Primary cilium,Cytosol,Perinuclear theca,Flagellar centriole

OverviewNCBI Gene

This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

659 residues, UniProt reviewed canonical sequence.

>Q8TAP6|CEP76
     1  MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE DLIKALRRRG
    61  IIDDVMKELN FVTDSVEQEL PSSPKQPICF DRQSTLKKTN IDPTRRYLYL QVLGGKAFLE
   121  HLQEPEPLPG QVCSTFTLCL HYRNQRFRSK PVPCACEPDF HDGFLLEVHR ESLGDGTRMA
   181  DSTTMLSISD PIHMVLIKTD IFGETTLVAS YFLEWRSVLG SENGVTSLTV ELMGVGTESK
   241  VSVGILNIKL EMYPPLNQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS
   301  HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER APVIGGGGKQ
   361  EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG TKAKGVPHAW VMTCGTDGAI
   421  TFWESLTGHR YIHKPTNPDE PPVAEQPKPL YPYRTIGCVF NHQMFLGNCQ PSDAVETCVF
   481  DLNDESKWKP MSEEAIKSVC APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR
   541  KDLGLTTVWE DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF
   601  VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM FACKYRSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP76 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

testis: 7.6 nTPM
thymus: 7.3 nTPM
cerebellum: 5.8 nTPM
bone marrow: 5.7 nTPM
esophagus: 4.9 nTPM
epididymis: 4.8 nTPM

Single-cell type

early spermatids: 293 nCPM
late primary spermatocytes: 76 nCPM
late spermatids: 72 nCPM
differentiating spermatogonia: 36 nCPM
undifferentiated spermatogonia: 36 nCPM
early primary spermatocytes: 35 nCPM

Immune cell

intermediate monocyte: 4.4 nTPM
NK-cell: 3.7 nTPM
MAIT T-cell: 3.5 nTPM
T-reg: 3.4 nTPM
naive CD8 T-cell: 3.3 nTPM
memory CD8 T-cell: 3.2 nTPM

Brain region

cerebellum: 16 nTPM
cerebral cortex: 5.9 nTPM
choroid plexus: 5.2 nTPM
hypothalamus: 5.2 nTPM
pons: 5 nTPM
white matter: 5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEP76.

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 117 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 1.75
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of centriole replication

Cellular components

Protein domainsUniProt · Pfam · InterPro

Papain-like cysteine peptidase superfamily
Centrosomal protein of 76 kDa, C-terminal
CEP76/DRC7, peptidase-like domain
Centrosomal protein of 76 kDa C-terminal domain
CEP76 peptidase-like domain
CEP76, C2 domain
Centrosomal protein of 76 kDa
CEP76, N-terminal
CEP76 C2 domain
CEP76 N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP76 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP76 as an antibody target. Whether an autoantibody or antibody against CEP76 could matter depends on whether native CEP76 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP76 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP76 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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