Seroatlas · Human Serome Atlas

IK

Protein Red

Also known as: RED, RED_HUMAN, RER

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13123
Gene: IK
Ensembl: ENSG00000113141
Chromosome: 5
Canonical length: 557 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>Q13123|IK
     1  MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM
    61  PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI
   121  STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS
   181  KEKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV
   241  VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK
   301  KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRDRERER
   361  ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP GSTKELIKSI NEKFAGSAGW
   421  EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR
   481  WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE
   541  KRKKMEADGV EVKRPKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 135 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 135 nTPM
skeletal muscle: 131 nTPM
bone marrow: 125 nTPM
choroid plexus: 112 nTPM
thymus: 106 nTPM
testis: 103 nTPM

Single-cell type

fallopian tube ciliated cells: 913 nCPM
late primary spermatocytes: 732 nCPM
respiratory ciliated cells: 652 nCPM
endometrial ciliated cells: 508 nCPM
epididymal efferent duct ciliated cells: 449 nCPM
esophageal apical cells: 432 nCPM

Immune cell

basophil: 350 nTPM
T-reg: 276 nTPM
total PBMC: 242 nTPM
eosinophil: 237 nTPM
neutrophil: 228 nTPM
naive CD4 T-cell: 210 nTPM

Brain region

hypothalamus: 85 nTPM
cerebral cortex: 84 nTPM
cerebellum: 76 nTPM
choroid plexus: 73 nTPM
white matter: 71 nTPM
midbrain: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0
gnomAD missense Z: 3.5
DepMap mean gene effect: -1.41
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein RED, C-terminal
RED-like, N-terminal
Protein Red-like
RED-like protein C-terminal region
RED-like protein N-terminal region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IK as an antibody target. Whether an autoantibody or antibody against IK could matter depends on whether native IK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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