Seroatlas · Human Serome Atlas

CEP70

Centrosomal protein of 70 kDa

Also known as: BITE, CEP70_HUMAN, FLJ13036

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NHQ1
Gene
CEP70
Ensembl
ENSG00000114107
Chromosome
3
Canonical length
597 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in cilium assembly and regulation of microtubule cytoskeleton organization. Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

597 residues, UniProt reviewed canonical sequence.

>Q8NHQ1|CEP70
     1  MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT DLKDLIIFDK
    61  QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL EQSRAANQEQ RANDLEQIME
   121  SVKSKIGELE DESLSRACHQ QNKIKDLQKE QKTLQVKCQH YKKKRTEQEE TIASLQMEVC
   181  RLKKEEEDRI VTQNRVFAYL CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS
   241  EEENDYRNLD ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK
   301  QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ VLCSINSIIH
   361  NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA DQLTSLKDLY KSLKTLSAEL
   421  VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE VENKEKDSNM PHFQTLQAIV SHFQKLFDVP
   481  SLNGVYPRMN EVYTRLGEMN NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV
   541  MQVLGPEDLQ SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • testis: 64 nTPM
  • duodenum: 53 nTPM
  • thymus: 39 nTPM
  • thyroid gland: 37 nTPM
  • retina: 33 nTPM
  • cervix: 29 nTPM

Single-cell type

  • late spermatids: 451 nCPM
  • late primary spermatocytes: 406 nCPM
  • alveolar cells type 2: 261 nCPM
  • fallopian tube ciliated cells: 260 nCPM
  • endometrial ciliated cells: 242 nCPM
  • transitional alveolar cells: 197 nCPM

Immune cell

  • naive CD4 T-cell: 4 nTPM
  • naive CD8 T-cell: 4 nTPM
  • MAIT T-cell: 3.3 nTPM
  • gdT-cell: 2.7 nTPM
  • memory CD8 T-cell: 2.3 nTPM
  • NK-cell: 2.2 nTPM

Brain region

  • hypothalamus: 54 nTPM
  • thalamus: 50 nTPM
  • cerebellum: 50 nTPM
  • medulla oblongata: 48 nTPM
  • midbrain: 47 nTPM
  • white matter: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
-0.04
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP70 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP70 as an antibody target. Whether an autoantibody or antibody against CEP70 could matter depends on whether native CEP70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP70 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEP70. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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