Seroatlas · Human Serome Atlas

GPKOW

G-patch domain and KOW motifs-containing protein

Also known as: GPATC5, GPATCH5, GPKOW_HUMAN, Mos2, Spp2, T54

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92917
Gene: GPKOW
Ensembl: ENSG00000068394
Chromosome: X
Canonical length: 476 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q92917|GPKOW
     1  MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK TVEGRELQSV
    61  KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV VSQAVKELIA ESKKSLEERE
   121  NAGVDPTLAI PMIQKGCTPS GEGADSEPRA ETVPEEANYE AVPVEAYGLA MLRGMGWKPG
   181  EGIGRTFNQV VKPRVNSLRP KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG
   241  LVPGGAVVVL SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN
   301  TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA APRSQHWLHR
   361  DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR VLEGLREDML ETLVPKAEGD
   421  RVMVVLGPQT GRVGHLLSRD RARSRALVQL PRENQVVELH YDAICQYMGP SDTDDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPKOW can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 35 nTPM
midbrain: 26 nTPM
tongue: 24 nTPM
choroid plexus: 23 nTPM
spinal cord: 23 nTPM
blood vessel: 23 nTPM

Single-cell type

oocytes: 60 nCPM
syncytiotrophoblasts: 54 nCPM
esophageal apical cells: 42 nCPM
cytotrophoblasts: 34 nCPM
decidual stromal cells: 27 nCPM
esophageal suprabasal cells: 27 nCPM

Immune cell

gdT-cell: 37 nTPM
non-classical monocyte: 36 nTPM
naive B-cell: 35 nTPM
intermediate monocyte: 31 nTPM
T-reg: 31 nTPM
MAIT T-cell: 30 nTPM

Brain region

thalamus: 41 nTPM
medulla oblongata: 38 nTPM
midbrain: 37 nTPM
white matter: 37 nTPM
cerebellum: 34 nTPM
spinal cord: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 0.92
DepMap mean gene effect: -1.02
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

G-patch domain
KOW
Large ribosomal subunit protein uL2, domain 2
KOW motif
Spp2/MOS2, G-patch domain
G-patch domain and KOW motifs-containing protein, KOW 1
G-patch domain and KOW motifs-containing protein, KOW 2
Pre-mRNA-splicing factor Spp2-like
G-patch domain
GPKOW C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPKOW in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPKOW as an antibody target. Whether an autoantibody or antibody against GPKOW could matter depends on whether native GPKOW is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPKOW is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPKOW as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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