Seroatlas · Human Serome Atlas

SH3BP5L

SH3 domain-binding protein 5-like

Also known as: 3BP5L_HUMAN, KIAA1720

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L8J4
Gene: SH3BP5L
Ensembl: ENSG00000175137
Chromosome: 1
Canonical length: 393 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q7L8J4|SH3BP5L
     1  MAELRQVPGG RETPQGELRP EVVEDEVPRS PVAEEPGGGG SSSSEAKLSP REEEELDPRI
    61  QEELEHLNQA SEEINQVELQ LDEARTTYRR ILQESARKLN TQGSHLGSCI EKARPYYEAR
   121  RLAKEAQQET QKAALRYERA VSMHNAAREM VFVAEQGVMA DKNRLDPTWQ EMLNHATCKV
   181  NEAEEERLRG EREHQRVTRL CQQAEARVQA LQKTLRRAIG KSRPYFELKA QFSQILEEHK
   241  AKVTELEQQV AQAKTRYSVA LRNLEQISEQ IHARRRGGLP PHPLGPRRSS PVGAEAGPED
   301  MEDGDSGIEG AEGAGLEEGS SLGPGPAPDT DTLSLLSLRT VASDLQKCDS VEHLRGLSDH
   361  VSLDGQELGT RSGGRRGSDG GARGGRHQRS VSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3BP5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 29 nTPM
cerebellum: 27 nTPM
cerebral cortex: 24 nTPM
esophagus: 22 nTPM
heart muscle: 20 nTPM
skin: 18 nTPM

Single-cell type

esophageal apical cells: 53 nCPM
neutrophils: 34 nCPM
platelets: 24 nCPM
neutrophil progenitors: 20 nCPM
retinal pigment epithelial cells: 17 nCPM
adrenal cortex cells: 16 nCPM

Immune cell

basophil: 7.7 nTPM
neutrophil: 4.7 nTPM
eosinophil: 4.1 nTPM
classical monocyte: 1.2 nTPM
myeloid DC: 1.1 nTPM
memory CD4 T-cell: 1 nTPM

Brain region

cerebral cortex: 27 nTPM
white matter: 23 nTPM
hippocampal formation: 22 nTPM
amygdala: 22 nTPM
basal ganglia: 21 nTPM
cerebellum: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.05
gnomAD missense Z: 1.68
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH3BP5L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3BP5L as an antibody target. Whether an autoantibody or antibody against SH3BP5L could matter depends on whether native SH3BP5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3BP5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH3BP5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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