Seroatlas · Human Serome Atlas

RELCH

RAB11-binding protein RELCH

Also known as: FLJ33841, HsT3308, HsT885, KIAA1468, RELCH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P260
Gene
RELCH
Ensembl
ENSG00000134444
Chromosome
18
Canonical length
1216 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Involved in intracellular cholesterol transport. Located in recycling endosome and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1216 residues, UniProt reviewed canonical sequence.

>Q9P260|RELCH
     1  MAAMAPGGSG SGGGVNPFLS DSDEDDDEVA ATEERRAVLR LGAGSGLDPG SAGSLSPQDP
    61  VALGSSARPG LPGEASAAAV ALGGTGETPA RLSIDAIAAQ LLRDQYLLTA LELHTELLES
   121  GRELPRLRDY FSNPGNFERQ SGTPPGMGAP GVPGAAGVGG AGGREPSTAS GGGQLNRAGS
   181  ISTLDSLDFA RYSDDGNRET DEKVAVLEFE LRKAKETIQA LRANLTKAAE HEVPLQERKN
   241  YKSSPEIQEP IKPLEKRALN FLVNEFLLKN NYKLTSITFS DENDDQDFEL WDDVGLNIPK
   301  PPDLLQLYRD FGNHQVTGKD LVDVASGVEE DELEALTPII SNLPPTLETP QPAENSMLVQ
   361  KLEDKISLLN SEKWSLMEQI RRLKSEMDFL KNEHFAIPAV CDSVQPPLDQ LPHKDSEDSG
   421  QHPDVNSSDK GKNTDIHLSI SDEADSTIPK ENSPNSFPRR EREGMPPSSL SSKKTVHFDK
   481  PNRKLSPAFH QALLSFCRMS ADSRLGYEVS RIADSEKSVM LMLGRCLPHI VPNVLLAKRE
   541  ELIPLILCTA CLHPEPKERD QLLHILFNLI KRPDDEQRQM ILTGCVAFAR HVGPTRVEAE
   601  LLPQCWEQIN HKYPERRLLV AESCGALAPY LPKEIRSSLV LSMLQQMLME DKADLVREAV
   661  IKSLGIIMGY IDDPDKYHQG FELLLSALGD PSERVVSATH QVFLPAYAAW TTELGNLQSH
   721  LILTLLNKIE KLLREGEHGL DEHKLHMYLS ALQSLIPSLF ALVLQNAPFS SKAKLHGEVP
   781  QIEVTRFPRP MSPLQDVSTI IGSREQLAVL LQLYDYQLEQ EGTTGWESLL WVVNQLLPQL
   841  IEIVGKINVT STACVHEFSR FFWRLCRTFG KIFTNTKVKP QFQEILRLSE ENIDSSAGNG
   901  VLTKATVPIY ATGVLTCYIQ EEDRKLLVGF LEDVMTLLSL SHAPLDSLKA SFVELGANPA
   961  YHELLLTVLW YGVVHTSALV RCTAARMFEL TLRGMSEALV DKRVAPALVT LSSDPEFSVR
  1021  IATIPAFGTI METVIQRELL ERVKMQLASF LEDPQYQDQH SLHTEIIKTF GRVGPNAEPR
  1081  FRDEFVIPHL HKLALVNNLQ IVDSKRLDIA THLFEAYSAL SCCFISEDLM VNHFLPGLRC
  1141  LRTDMEHLSP EHEVILSSMI KECEQKVENK TVQEPQGSMS IAASLVSEDT KTKFLNKMGQ
  1201  LTTSGAMLAN VFQRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RELCH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 24 nTPM
  • skin: 20 nTPM
  • vagina: 16 nTPM
  • retina: 15 nTPM
  • cerebellum: 14 nTPM
  • cervix: 14 nTPM

Single-cell type

  • esophageal apical cells: 454 nCPM
  • prostatic glandular cells: 256 nCPM
  • neutrophil progenitors: 225 nCPM
  • microglia: 205 nCPM
  • gonadotrophs: 198 nCPM
  • thyrotrophs: 197 nCPM

Immune cell

  • neutrophil: 1.7 nTPM
  • basophil: 1.4 nTPM
  • naive CD8 T-cell: 1.3 nTPM
  • T-reg: 1.3 nTPM
  • eosinophil: 1.2 nTPM
  • gdT-cell: 1.1 nTPM

Brain region

  • cerebellum: 23 nTPM
  • basal ganglia: 22 nTPM
  • cerebral cortex: 20 nTPM
  • hippocampal formation: 20 nTPM
  • hypothalamus: 20 nTPM
  • white matter: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RELCH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RELCH as an antibody target. Whether an autoantibody or antibody against RELCH could matter depends on whether native RELCH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RELCH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RELCH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RELCH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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