Seroatlas · Human Serome Atlas

NFKBIL1

NF-kappa-B inhibitor-like protein 1

Also known as: IKBL, IKBL1_HUMAN, NFKBIL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBC1
Gene
NFKBIL1
Ensembl
ENSG00000204498
Chromosome
6
Canonical length
381 aa
Protein class
Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q9UBC1|NFKBIL1
     1  MSNPSPQVPE EEASTSVCRP KSSMASTSRR QRRERRFRRY LSAGRLVRAQ ALLQRHPGLD
    61  VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT ALHAAARQGP DAYTDFFLPL
   121  LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS AEEEEEDDAS KEREWRQKLQ GELEDEWQEV
   181  MGRFEGDASH ETQEPESFSA WSDRLAREHA QKCQQQQREA EGSRRPPRAE GSSQSWRQQE
   241  EEQRLFRERA RAKEEELRES RARRAQEALG DREPKPTRAG PREEHPRGAG RGSLWRFGDV
   301  PWPCPGGGDP EAMAAALVAR GPPLEEQGAL RRYLRVQQVR WHPDRFLQRF RSQIETWELG
   361  RVMGAVTALS QALNRHAEAL K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFKBIL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 41 nTPM
  • ovary: 33 nTPM
  • stomach: 29 nTPM
  • skeletal muscle: 27 nTPM
  • colon: 26 nTPM
  • blood vessel: 24 nTPM

Single-cell type

  • bergmann glia: 16 nCPM
  • astrocytes: 12 nCPM
  • other brain neurons: 11 nCPM
  • oligodendrocytes: 11 nCPM
  • brain excitatory neurons: 9.6 nCPM
  • distal convoluted tubule cells: 9.4 nCPM

Immune cell

  • non-classical monocyte: 0.9 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • classical monocyte: 0.3 nTPM
  • myeloid DC: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • basophil: 0.2 nTPM

Brain region

  • cerebral cortex: 1 nTPM
  • midbrain: 0.8 nTPM
  • white matter: 0.8 nTPM
  • cerebellum: 0.7 nTPM
  • hypothalamus: 0.7 nTPM
  • medulla oblongata: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NFKBIL1.

Disease | AllUniProt

Conditions NFKBIL1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.03
gnomAD missense Z
2.29
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFKBIL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFKBIL1 as an antibody target. Whether an autoantibody or antibody against NFKBIL1 could matter depends on whether native NFKBIL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFKBIL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFKBIL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NFKBIL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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