Seroatlas · Human Serome Atlas

ZCCHC17

Zinc finger CCHC domain-containing protein 17

Also known as: HSPC251, pNO40, PS1D, ZCC17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP64
Gene: ZCCHC17
Ensembl: ENSG00000121766
Chromosome: 1
Canonical length: 241 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in RNA stabilization. Predicted to be located in nucleolus. Predicted to be part of cytosolic large ribosomal subunit. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q9NP64|ZCCHC17
     1  MNSGRPETME NLPALYTIFQ GEVAMVTDYG AFIKIPGCRK QGLVHRTHMS SCRVDKPSEI
    61  VDVGDKVWVK LIGREMKNDR IKVSLSMKVV NQGTGKDLDP NNVIIEQEER RRRSFQDYTG
   121  QKITLEAVLN TTCKKCGCKG HFAKDCFMQP GGTKYSLIPD EEEEKEEAKS AEFEKPDPTR
   181  NPSRKRKKEK KKKKHRDRKS SDSDSSDSES DTGKRARHTS KDSKAAKKKK KKKKHKKKHK
   241  E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCCHC17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 138 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 138 nTPM
amygdala: 79 nTPM
midbrain: 73 nTPM
cerebral cortex: 73 nTPM
hypothalamus: 71 nTPM
hippocampal formation: 69 nTPM

Single-cell type

platelets: 358 nCPM
early primary spermatocytes: 344 nCPM
cardiomyocytes: 340 nCPM
megakaryocytes: 241 nCPM
sertoli cells: 179 nCPM
late spermatids: 175 nCPM

Immune cell

basophil: 87 nTPM
eosinophil: 60 nTPM
total PBMC: 52 nTPM
naive B-cell: 48 nTPM
naive CD8 T-cell: 46 nTPM
memory CD8 T-cell: 43 nTPM

Brain region

white matter: 77 nTPM
midbrain: 73 nTPM
pons: 70 nTPM
cerebral cortex: 67 nTPM
hippocampal formation: 65 nTPM
hypothalamus: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.01
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

RNA stabilization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCHC-type
S1 domain
Nucleic acid-binding, OB-fold
S1 RNA binding domain
Zinc finger CCHC domain-containing protein 17, S1 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZCCHC17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCCHC17 as an antibody target. Whether an autoantibody or antibody against ZCCHC17 could matter depends on whether native ZCCHC17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCCHC17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCCHC17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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