Seroatlas · Human Serome Atlas

PNISR

Arginine/serine-rich protein PNISR

Also known as: bA98I9.2, C6orf111, DKFZp564B0769, FLJ14752, PNISR_HUMAN, SFRS18, SRrp130

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF01
Gene: PNISR
Ensembl: ENSG00000132424
Chromosome: 6
Canonical length: 805 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

805 residues, UniProt reviewed canonical sequence.

>Q8TF01|PNISR
     1  MWDQGGQPWQ QWPLNQQQWM QSFQHQQDPS QIDWAALAQA WIAQREASGQ QSMVEQPPGM
    61  MPNGQDMSTM ESGPNNHGNF QGDSNFNRMW QPEWGMHQQP PHPPPDQPWM PPTPGPMDIV
   121  PPSEDSNSQD SGEFAPDNRH IFNQNNHNFG GPPDNFAVGP VNQFDYQHGA AFGPPQGGFH
   181  PPYWQPGPPG PPAPPQNRRE RPSSFRDRQR SPIALPVKQE PPQIDAVKRR TLPAWIREGL
   241  EKMEREKQKK LEKERMEQQR SQLSKKEKKA TEDAEGGDGP RLPQRSKFDS DEEEEDTENV
   301  EAASSGKVTR SPSPVPQEEH SDPEMTEEEK EYQMMLLTKM LLTEILLDVT DEEIYYVAKD
   361  AHRKATKAPA KQLAQSSALA SLTGLGGLGG YGSGDSEDER SDRGSESSDT DDEELRHRIR
   421  QKQEAFWRKE KEQQLLHDKQ MEEEKQQTER VTKEMNEFIH KEQNSLSLLE AREADGDVVN
   481  EKKRTPNETT SVLEPKKEHK EKEKQGRSRS GSSSSGSSSS NSRTSSTSST VSSSSYSSSS
   541  GSSRTSSRSS SPKRKKRHSR SRSPTIKARR SRSRSYSRRI KIESNRARVK IRDRRRSNRN
   601  SIERERRRNR SPSRERRRSR SRSRDRRTNR ASRSRSRDRR KIDDQRGNLS GNSHKHKGEA
   661  KEQERKKERS RSIDKDRKKK DKEREREQDK RKEKQKREEK DFKFSSQDDR LKRKRESERT
   721  FSRSGSISVK IIRHDSRQDS KKSTTKDSKK HSGSDSSGRS SSESPGSSKE KKAKKPKHSR
   781  SRSVEKSQRS GKKASRKHKS KSRSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNISR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 128 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 128 nTPM
ovary: 103 nTPM
bone marrow: 101 nTPM
thyroid gland: 97 nTPM
colon: 97 nTPM
retina: 95 nTPM

Single-cell type

leydig cells: 867 nCPM
pituitary stem cells: 586 nCPM
pituicytes/fscs: 581 nCPM
sertoli cells: 579 nCPM
somatotrophs: 578 nCPM
epididymal principal cells: 574 nCPM

Immune cell

neutrophil: 30 nTPM
naive B-cell: 26 nTPM
NK-cell: 24 nTPM
plasmacytoid DC: 20 nTPM
memory B-cell: 19 nTPM
naive CD4 T-cell: 18 nTPM

Brain region

cerebellum: 118 nTPM
choroid plexus: 98 nTPM
cerebral cortex: 83 nTPM
white matter: 79 nTPM
medulla oblongata: 77 nTPM
thalamus: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 1.61
DepMap mean gene effect: -0.46
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

PNN-interacting serine/arginine-rich protein
Arginine/serine-rich protein PNISR

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PNISR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNISR as an antibody target. Whether an autoantibody or antibody against PNISR could matter depends on whether native PNISR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNISR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNISR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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