p21 activated kinase binding domain

Definition

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases. It is also known as the Cdc42/Rac interactive binding (CRIB) motif. It has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. This subgroup of CRIB/PBD-domains is found N-terminal of Serine/Threonine kinase domains in PAK and PAK-like proteins [[cite:PMID:10802735], [cite:PMID:11418196], [cite:PMID:9119069], [cite:PMID:9009270]].

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• PAK1
• PAK2
• PAK3
• PAK4
• PAK5
• PAK6