Seroatlas · Human Serome Atlas

FBXO28

F-box only protein 28

Also known as: CENP-30, Fbx28, FBX28_HUMAN, FLJ10766, KIAA0483

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVF7
Gene: FBXO28
Ensembl: ENSG00000143756
Chromosome: 1
Canonical length: 368 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Focal adhesion sites

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>Q9NVF7|FBXO28
     1  MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA PALAPDQLPQ
    61  NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR MLNQGFLKVE RYHNLCQKQV
   121  KAQLPRRESE RRNHSLARHA DILAAVETRL SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV
   181  LRYVNSTRAP QRAHEVLQEL RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG
   241  PSAALTTMQL FSKQNPSRQE VTKLQQQVKT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD
   301  QKLLEQTQII GEQNARLAEL ERKLREVMES AVGNSSGSGQ NEESPRKRKK ATEAIDSLRK
   361  SKRLRNRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

skin: 20 nTPM
liver: 16 nTPM
tongue: 13 nTPM
parathyroid gland: 13 nTPM
kidney: 13 nTPM
esophagus: 12 nTPM

Single-cell type

esophageal apical cells: 126 nCPM
myonuclei: 122 nCPM
choroid plexus epithelial cells: 115 nCPM
proximal tubule cells: 98 nCPM
adrenal cortex cells: 88 nCPM
b-cells: 86 nCPM

Immune cell

eosinophil: 12 nTPM
memory B-cell: 9 nTPM
naive B-cell: 9 nTPM
T-reg: 8.9 nTPM
NK-cell: 8.6 nTPM
myeloid DC: 7.8 nTPM

Brain region

cerebral cortex: 21 nTPM
hypothalamus: 21 nTPM
cerebellum: 20 nTPM
pons: 20 nTPM
white matter: 20 nTPM
spinal cord: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBXO28.

Disease | AllUniProt

Conditions FBXO28 is implicated in, by any mechanism.

Developmental and epileptic encephalopathy 100 (DEE100) MIM:619777

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 84 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental and epileptic encephalopathy 100
Inborn genetic diseases
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.99
gnomAD missense Z: 2.27
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO28 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO28 as an antibody target. Whether an autoantibody or antibody against FBXO28 could matter depends on whether native FBXO28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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