Seroatlas · Human Serome Atlas

MIS18A

Protein Mis18-alpha

Also known as: B28, C21orf45, C21orf46, FASP1, hMis18alpha, MS18A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYP9
Gene: MIS18A
Ensembl: ENSG00000159055
Chromosome: 21
Canonical length: 233 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in CENP-A containing chromatin assembly and chromosome segregation. Predicted to act upstream of or within pericentric heterochromatin organization and protein localization to chromosome, centromeric region. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>Q9NYP9|MIS18A
     1  MAGVRSLRCS RGCAGGCECG DKGKCSDSSL LGKRLSEDSS RHQLLQKWAS MWSSMSEDAS
    61  VADMERAQLE EEAAAAEERP LVFLCSGCRR PLGDSLSWVA SQEDTNCILL RCVSCNVSVD
   121  KEQKLSKREK ENGCVLETLC CAGCSLNLGY VYRCTPKNLD YKRDLFCLSV EAIESYVLGS
   181  SEKQIVSEDK ELFNLESRVE IEKSLTQMED VLKALQMKLW EAESKLSFAT CKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIS18A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
bone marrow: 16 nTPM
thymus: 15 nTPM
tonsil: 11 nTPM
lymph node: 10 nTPM
rectum: 10 nTPM

Single-cell type

early primary spermatocytes: 121 nCPM
oocytes: 101 nCPM
differentiating spermatogonia: 97 nCPM
late primary spermatocytes: 70 nCPM
erythrocyte progenitors: 66 nCPM
extravillous trophoblasts: 61 nCPM

Immune cell

memory B-cell: 30 nTPM
naive B-cell: 30 nTPM
T-reg: 24 nTPM
naive CD4 T-cell: 22 nTPM
plasmacytoid DC: 20 nTPM
non-classical monocyte: 20 nTPM

Brain region

cerebellum: 6.4 nTPM
cerebral cortex: 5.8 nTPM
hippocampal formation: 5.6 nTPM
white matter: 5.6 nTPM
basal ganglia: 5 nTPM
amygdala: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.01
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.74
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIS18A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIS18A as an antibody target. Whether an autoantibody or antibody against MIS18A could matter depends on whether native MIS18A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIS18A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIS18A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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