Seroatlas · Human Serome Atlas

CCSER2

Serine-rich coiled-coil domain-containing protein 2

Also known as: CCSE2_HUMAN, FAM190B, KIAA1128

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7U1
Gene: CCSER2
Ensembl: ENSG00000107771
Chromosome: 10
Canonical length: 834 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Predicted to be involved in microtubule bundle formation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

834 residues, UniProt reviewed canonical sequence.

>Q9H7U1|CCSER2
     1  MEEKTQIKTF LGSKLPKYGT KSVRSTLQPM PNGTPVNLLG TSKNSNVKSY IKNNGSDCPS
    61  SHSFNWRKAN KYQLCAQGVE EPNNTQNSHD KIIDPEKRVP TQGMFDKNGI KGGLKSVSLF
   121  TSKLAKPSTM FVSSTEELNQ KSFSGPSNLG KFTKGTLLGR TSYSSINTPK SQLNGFYGNR
   181  SAGSMQRPRA NSCATRSSSG ESLAQSPDSS KSINCEKMVR SQSFSHSIQN SFLPPSSITR
   241  SHSFNRAVDL TKPYQNQQLS IRVPLRSSML TRNSRQPEVL NGNEHLGYGF NRPYAAGGKK
   301  LALPNGPGVT STLGYRMVHP SLLKSSRSPF SGTMTVDGNK NSPADTCVEE DATVLAKDRA
   361  ANKDQELIEN ESYRTKNNQT MKHDAKMRYL SDDVDDISLS SLSSSDKNDL SEDFSDDFID
   421  IEDSNRTRIT PEEMSLKEEK HENGPPQDMF DSPKENEKAF SKTDEWIDIS VSDRSECTKH
   481  TSGNNLVSPD TDYRAGSSFE LSPSDSSDGT YMWDEEGLEP IGNVHPVGSY ESSEMNSIDI
   541  LNNLESCDLE DDDLMLDVDL PEDAPLENVE CDNMNRFDRP DRNVRQPQEG FWKRPPQRWS
   601  GQEHYHLSHP DHYHHHGKSD LSRGSPYRES PLGHFESYGG MPFFQAQKMF VDVPENTVIL
   661  DEMTLRHMVQ DCTAVKTQLL KLKRLLHQHD GSGSLHDIQL SLPSSPEPED GDKVYKNEDL
   721  LNEIKQLKDE IKKKDEKIQL LELQLATQHI CHQKCKEEKC TYADKYTQTP WRRIPGGYSA
   781  PSFSPWQGSF QGIPRTVPPH RRQTSSTTAF QQPSQTHRSH PGKTNKATTY RGPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCSER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 62 nTPM
testis: 59 nTPM
tongue: 59 nTPM
heart muscle: 52 nTPM
esophagus: 26 nTPM
cerebral cortex: 24 nTPM

Single-cell type

late spermatids: 8,993 nCPM
early spermatids: 2,730 nCPM
nk-cells: 444 nCPM
t-cells: 386 nCPM
myonuclei: 345 nCPM
oligodendrocytes: 319 nCPM

Immune cell

NK-cell: 21 nTPM
MAIT T-cell: 20 nTPM
gdT-cell: 20 nTPM
memory CD8 T-cell: 18 nTPM
memory CD4 T-cell: 14 nTPM
naive CD8 T-cell: 14 nTPM

Brain region

thalamus: 98 nTPM
pons: 97 nTPM
medulla oblongata: 96 nTPM
cerebellum: 90 nTPM
hypothalamus: 90 nTPM
spinal cord: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.67
gnomAD missense Z: -0.07
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Serine-rich coiled-coil domain-containing protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCSER2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NDEL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCSER2 as an antibody target. Whether an autoantibody or antibody against CCSER2 could matter depends on whether native CCSER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCSER2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCSER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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