Seroatlas · Human Serome Atlas

DIXDC1

Dixin

Also known as: DIXC1_HUMAN, Dixin, KIAA1735

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q155Q3
Gene: DIXDC1
Ensembl: ENSG00000150764
Chromosome: 11
Canonical length: 683 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

683 residues, UniProt reviewed canonical sequence.

>Q155Q3|DIXDC1
     1  MLACLTRGNL LDVLQEGFNE QQLQAYVAWV NAQLKKRPAV KPVQDLRQDL RDGVILAYLI
    61  EIVAGEKLSG VQLSPGNQQE MKNNVEKVLQ FVASKKIRMH QTSAKDIVDG NLKSIMRLVL
   121  ALAAHFKPGS SRTVNQGRDS RAPLQSHRPH CATAVAQGAA AALADVCHDM SRSGRDVFRY
   181  RQRNSSMDEE IENPYWSVRA LVQQYEGQQR SPSESSCSSL TSPSPIHSAK SESIITQSEE
   241  KADFVIIPAE GIENRTEGTD SPLSRDWRPG SPGTYLETSW EEQLLEQQEY LEKEMEEAKK
   301  MISGLQALLL NGSLPEDEQE RPLALCEPGV NPEEQLIIIQ SRLDQSMEEN QDLKKELLKC
   361  KQEARNLQGI KDALQQRLTQ QDTSVLQLKQ ELLRANMDKD ELHNQNVDLQ RKLDERNRLL
   421  GEYKKELGQK DRLLQQHQAK LEEALRKLSD VSYHQVDLER ELEHKDVLLA HCMKREADEA
   481  TNYNSHNSQS NGFLLPTAGK GATSVSNRGT SDLQLVRDAL RSLRNSFSGH DPQHHTIDSL
   541  EQGISSLMER LHVMETQKKQ ERKVRVKSPR TQVGSEYRES WPPNSKLPHS QSSPTVSSTC
   601  TKVLYFTDRS LTPFMVNIPK RLEEVTLKDF KAAIDREGNH RYHFKALDPE FGTVKEEIFH
   661  DDDAIPGWEG KIVAWVEEDH GEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIXDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 42 nTPM
seminal vesicle: 34 nTPM
blood vessel: 30 nTPM
colon: 28 nTPM
spinal cord: 25 nTPM
urinary bladder: 25 nTPM

Single-cell type

respiratory ciliated cells: 296 nCPM
rod photoreceptor cells: 253 nCPM
cone photoreceptor cells: 253 nCPM
ependymal cells: 245 nCPM
proximal tubule cells: 236 nCPM
choroid plexus epithelial cells: 223 nCPM

Immune cell

eosinophil: 5.2 nTPM
naive CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
neutrophil: 0.4 nTPM
gdT-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM

Brain region

cerebellum: 86 nTPM
white matter: 78 nTPM
choroid plexus: 58 nTPM
basal ganglia: 57 nTPM
midbrain: 55 nTPM
cerebral cortex: 54 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DIXDC1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 53 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Obesity

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.41
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DIXDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIXDC1 as an antibody target. Whether an autoantibody or antibody against DIXDC1 could matter depends on whether native DIXDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIXDC1 is annotated at the cell surface, where native DIXDC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DIXDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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