PAS fold
IPR013767
Definition
PAS domains are involved in many signalling proteins where they are used as a signal sensor domain PMID:10357859. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. The PAS domain was named after three proteins that it occurs in: Per- period circadian protein Arnt- Ah receptor nuclear translocator protein Sim- single-minded protein. PAS domains are often associated with PAC domains [interpro:IPR001610]. It appears that these domains are directly linked, and that together they form the conserved 3D PAS fold. The division between the PAS and PAC domains is caused by major differences in sequences in the region connecting these two motifs PMID:15009198. In human PAS kinase, this region has been shown to be very flexible, and adopts different conformations depending on the bound ligand PMID:12377121. Probably the most surprising identification of a PAS domain was that in EAG-like K-channels PMID:9301332.
19 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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