Seroatlas · Human Serome Atlas

PPARA

Peroxisome proliferator-activated receptor alpha

Also known as: hPPAR, NR1C1, PPAR, PPARA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q07869
Gene
PPARA
Ensembl
ENSG00000186951
Chromosome
22
Canonical length
468 aa
Protein class
FDA approved drug targets, Metabolic proteins, Nuclear receptors, Predicted intracellular proteins, Transcription factors, Transporters
Subcellular location
Nucleoplasm,Primary cilium,Centriolar satellite,Basal body

OverviewNCBI Gene

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q07869|PPARA
     1  MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG FTEYQYLGSC
    61  PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI ECRICGDKAS GYHYGVHACE
   121  GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE
   181  KAKLKAEILT CEHDIEDSET ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV
   241  IHDMETLCMA EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL
   301  DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP FCDIMEPKFD
   361  FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM QEGIVHVLRL HLQSNHPDDI
   421  FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT ESDAALHPLL QEIYRDMY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPARA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 40 nTPM
  • liver: 31 nTPM
  • heart muscle: 26 nTPM
  • skeletal muscle: 24 nTPM
  • kidney: 21 nTPM
  • small intestine: 18 nTPM

Single-cell type

  • rod photoreceptor cells: 680 nCPM
  • proximal tubule cells: 571 nCPM
  • hepatocytes: 327 nCPM
  • enterocytes: 313 nCPM
  • choroid plexus epithelial cells: 263 nCPM
  • retinal pigment epithelial cells: 247 nCPM

Immune cell

  • eosinophil: 9.8 nTPM
  • plasmacytoid DC: 2.9 nTPM
  • T-reg: 1.3 nTPM
  • basophil: 1.2 nTPM
  • intermediate monocyte: 1 nTPM
  • gdT-cell: 0.9 nTPM

Brain region

  • choroid plexus: 50 nTPM
  • basal ganglia: 29 nTPM
  • thalamus: 29 nTPM
  • medulla oblongata: 28 nTPM
  • midbrain: 27 nTPM
  • white matter: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0.03
gnomAD missense Z
1.81
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPARA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPARA as an antibody target. Whether an autoantibody or antibody against PPARA could matter depends on whether native PPARA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPARA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPARA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPARA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...