Seroatlas · Human Serome Atlas

NR2F2

COUP transcription factor 2

Also known as: ARP1, COT2_HUMAN, COUP-TFII, COUPTF2, COUPTFB, NF-E3, SVP40, TFCOUP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P24468
Gene
NR2F2
Ensembl
ENSG00000185551
Chromosome
15
Canonical length
414 aa
Protein class
Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>P24468|NR2F2
     1  MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ
    61  GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN
   121  CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG
   181  YISLLLRAEP YPTSRFGSQC MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD
   241  QVALLRLTWS ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE
   301  KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF
   361  GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML LSGSSFNWPY MAIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NR2F2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
224 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 224 nTPM
  • blood vessel: 145 nTPM
  • cervix: 122 nTPM
  • seminal vesicle: 119 nTPM
  • endometrium: 116 nTPM
  • spleen: 100 nTPM

Single-cell type

  • peritubular myoid cells: 688 nCPM
  • pericytes: 683 nCPM
  • lymphatic endothelial cells: 528 nCPM
  • leydig cells: 527 nCPM
  • endometrial stromal cells: 471 nCPM
  • vascular smooth muscle cells: 458 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 101 nTPM
  • amygdala: 68 nTPM
  • thalamus: 67 nTPM
  • choroid plexus: 49 nTPM
  • midbrain: 46 nTPM
  • cerebral cortex: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NR2F2.

Disease | AllUniProt

Conditions NR2F2 is implicated in, by any mechanism.

  • Congenital heart defects, multiple types, 4 (CHTD4) MIM:615779
  • 46,XX sex reversal 5 (SRXX5) MIM:618901

Disease | GeneticClinVar

36 pathogenic / likely-pathogenic of 176 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
0.99
gnomAD missense Z
3.6
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NR2F2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NR2F2 as an antibody target. Whether an autoantibody or antibody against NR2F2 could matter depends on whether native NR2F2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NR2F2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NR2F2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NR2F2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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