BRD1
Bromodomain-containing protein 1
Also known as: BRD1_HUMAN, BRL, BRPF2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95696
- Gene
- BRD1
- Ensembl
- ENSG00000100425
- Chromosome
- 22
- Canonical length
- 1058 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear speckles
OverviewNCBI Gene
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Canonical amino-acid sequenceUniProt
1058 residues, UniProt reviewed canonical sequence.
>O95696|BRD1
1 MRRKGRCHRG SAARHPSSPC SVKHSPTRET LTYAQAQRMV EIEIEGRLHR ISIFDPLEII
61 LEDDLTAQEM SECNSNKENS ERPPVCLRTK RHKNNRVKKK NEALPSAHGT PASASALPEP
121 KVRIVEYSPP SAPRRPPVYY KFIEKSAEEL DNEVEYDMDE EDYAWLEIVN EKRKGDCVPA
181 VSQSMFEFLM DRFEKESHCE NQKQGEQQSL IDEDAVCCIC MDGECQNSNV ILFCDMCNLA
241 VHQECYGVPY IPEGQWLCRH CLQSRARPAD CVLCPNKGGA FKKTDDDRWG HVVCALWIPE
301 VGFANTVFIE PIDGVRNIPP ARWKLTCYLC KQKGVGACIQ CHKANCYTAF HVTCAQKAGL
361 YMKMEPVKEL TGGGTTFSVR KTAYCDVHTP PGCTRRPLNI YGDVEMKNGV CRKESSVKTV
421 RSTSKVRKKA KKAKKALAEP CAVLPTVCAP YIPPQRLNRI ANQVAIQRKK QFVERAHSYW
481 LLKRLSRNGA PLLRRLQSSL QSQRSSQQRE NDEEMKAAKE KLKYWQRLRH DLERARLLIE
541 LLRKREKLKR EQVKVEQVAM ELRLTPLTVL LRSVLDQLQD KDPARIFAQP VSLKEVPDYL
601 DHIKHPMDFA TMRKRLEAQG YKNLHEFEED FDLIIDNCMK YNARDTVFYR AAVRLRDQGG
661 VVLRQARREV DSIGLEEASG MHLPERPAAA PRRPFSWEDV DRLLDPANRA HLGLEEQLRE
721 LLDMLDLTCA MKSSGSRSKR AKLLKKEIAL LRNKLSQQHS QPLPTGPGLE GFEEDGAALG
781 PEAGEEVLPR LETLLQPRKR SRSTCGDSEV EEESPGKRLD AGLTNGFGGA RSEQEPGGGL
841 GRKATPRRRC ASESSISSSN SPLCDSSFNA PKCGRGKPAL VRRHTLEDRS ELISCIENGN
901 YAKAARIAAE VGQSSMWIST DAAASVLEPL KVVWAKCSGY PSYPALIIDP KMPRVPGHHN
961 GVTIPAPPLD VLKIGEHMQT KSDEKLFLVL FFDNKRSWQW LPKSKMVPLG IDETIDKLKM
1021 MEGRNSSIRK AVRIAFDRAM NHLSRVHGEP TSDLSDIDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- testis: 28 nTPM
- cerebellum: 24 nTPM
- skin: 21 nTPM
- skeletal muscle: 15 nTPM
- ovary: 14 nTPM
- bone marrow: 14 nTPM
Single-cell type
- innate lymphoid cells: 204 nCPM
- nk-cells: 123 nCPM
- endometrial glandular cells: 108 nCPM
- t-cells: 106 nCPM
- corticotrophs: 95 nCPM
- myonuclei: 89 nCPM
Immune cell
- non-classical monocyte: 2.8 nTPM
- MAIT T-cell: 1 nTPM
- naive CD8 T-cell: 1 nTPM
- memory CD8 T-cell: 0.9 nTPM
- memory CD4 T-cell: 0.8 nTPM
- naive CD4 T-cell: 0.8 nTPM
Brain region
- cerebellum: 38 nTPM
- cerebral cortex: 24 nTPM
- white matter: 23 nTPM
- choroid plexus: 22 nTPM
- hippocampal formation: 21 nTPM
- medulla oblongata: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.25
- gnomAD pLI
- 1
- gnomAD missense Z
- 2.76
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- chromatin remodeling
- erythrocyte maturation
- positive regulation of erythrocyte differentiation
- regulation of developmental process
- regulation of DNA-templated transcription
- regulation of hemopoiesis
- regulation of transcription by RNA polymerase II
- response to electrical stimulus
- response to immobilization stress
Molecular functions
- histone reader activity
- zinc ion binding
- unmodified histone reader activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- PWWP domain
- Bromodomain
- Zinc finger, PHD-type
- Zinc finger, FYVE/PHD-type
- Zinc finger, RING/FYVE/PHD-type
- Bromodomain, conserved site
- Enhancer of polycomb-like, N-terminal
- Zinc finger, PHD-type, conserved site
- Zinc finger, PHD-finger
- Extended PHD (ePHD) domain
- Bromodomain-like superfamily
- Histone Modification Regulator
- Bromodomain
- PWWP domain
- Enhancer of polycomb-like
- PHD-finger
- PHD-zinc-finger like domain
- BRPF2, ePHD domain
- BRPF2, PHD domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of BRD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BRD1 as an antibody target. Whether an autoantibody or antibody against BRD1 could matter depends on whether native BRD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BRD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label BRD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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