Seroatlas · Human Serome Atlas

NOC4L

Nucleolar complex protein 4 homolog

Also known as: MGC3162, NET49, Noc4, NOC4L_HUMAN, UTP19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVI4
Gene: NOC4L
Ensembl: ENSG00000184967
Chromosome: 12
Canonical length: 516 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

516 residues, UniProt reviewed canonical sequence.

>Q9BVI4|NOC4L
     1  MEREPGAAGV RRALGRRLEA VLASRSEANA VFDILAVLQS EDQEEIQEAV RTCSRLFGAL
    61  LERGELFVGQ LPSEEMVMTG SQGATRKYKV WMRHRYHSCC NRLGELLGHP SFQVKELALS
   121  ALLKFVQLEG AHPLEKSKWE GNYLFPRELF KLVVGGLLSP EEDQSLLLSQ FREYLDYDDT
   181  RYHTMQAAVD AVARVTGQHP EVPPAFWNNA FTLLSAVSLP RREPTVSSFY VKRAELWDTW
   241  KVAHLKEHRR VFQAMWLSFL KHKLPLSLYK KVLLIVHDAI LPQLAQPTLM IDFLTRACDL
   301  GGALSLLALN GLFILIHKHN LEYPDFYRKL YGLLDPSVFH VKYRARFFHL ADLFLSSSHL
   361  PAYLVAAFAK RLARLALTAP PEALLMVLPF ICNLLRRHPA CRVLVHRPHG PELDADPYDP
   421  GEEDPAQSRA LESSLWELQA LQRHYHPEVS KAASVINQAL SMPEVSIAPL LELTAYEIFE
   481  RDLKKKGPEP VPLEFIPAQG LLGRPGELCA QHFTLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOC4L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

testis: 32 nTPM
skeletal muscle: 23 nTPM
skin: 15 nTPM
ovary: 13 nTPM
esophagus: 13 nTPM
pancreas: 13 nTPM

Single-cell type

late spermatids: 107 nCPM
undifferentiated spermatogonia: 99 nCPM
oocytes: 74 nCPM
early spermatids: 73 nCPM
late primary spermatocytes: 55 nCPM
differentiating spermatogonia: 44 nCPM

Immune cell

plasmacytoid DC: 13 nTPM
intermediate monocyte: 12 nTPM
myeloid DC: 11 nTPM
naive B-cell: 11 nTPM
memory B-cell: 9.1 nTPM
non-classical monocyte: 9.1 nTPM

Brain region

hippocampal formation: 8 nTPM
white matter: 7.9 nTPM
medulla oblongata: 7.7 nTPM
cerebral cortex: 7.6 nTPM
hypothalamus: 7.3 nTPM
pons: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0
gnomAD missense Z: -2.47
DepMap mean gene effect: -0.95
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

rRNA processing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOC4L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOC4L as an antibody target. Whether an autoantibody or antibody against NOC4L could matter depends on whether native NOC4L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOC4L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOC4L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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