Seroatlas · Human Serome Atlas

BAHD1

Bromo adjacent homology domain-containing 1 protein

Also known as: BAHD1_HUMAN, KIAA0945

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBE0
Gene: BAHD1
Ensembl: ENSG00000140320
Chromosome: 15
Canonical length: 780 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables chromatin binding activity. Involved in heterochromatin formation and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

780 residues, UniProt reviewed canonical sequence.

>Q8TBE0|BAHD1
     1  MTHTRRKSLP MLSSGLTGRR EPLQMEDSNM EQGVEGVEPG MPESPGHLTG RRKNYPLRKR
    61  PLVPEKPKAC KVLLTRLENV AGPRSADEAD ELPPDLPKPP SPAPSSEDPG LAQPRKRRLA
   121  SLNAEALNNL LLEREDTSSL AGTRRSRAGD PHRSRDRDRA TGGWSSSKKR PRLGDLGGGS
   181  RDLSPEPAPD EGPRRDGDPA PKRLASLNAA AFLKLSQERE LPLRLPRAHA EVDGRSTEPP
   241  APKAPRPKWP KVNGKNYPKA WQGASSGEAA GPPGWQGCPD EPWPSATPCG PSVQPSHQPL
   301  SKALESPLGL RPHLPLLMGG QAALKPEPGR PGEESPAPKQ ELHQPSFPTP QLSPLPMPGN
   361  PADYNGLCVG PELTALGSFY LYCGQEGLQC GGYSPCPMLP EGKLSPVAAP HEEGLLLAPS
   421  SVPSGTPFQH PPWGSSRYCS SEDTGVNGYS ICGVLPLSVT HAGTTCGGCP YKMPFAAEGC
   481  RSLGQLEFPL PEAGHPASPA HPLLGCPVPS VPPAAEPVPH LQTPTSEPQT VARACPQSAK
   541  PPSGSKSGLR TGSSCRHTAR SKAARRPSHP KQPRVQRPRP RRRRRRRTNG WVPVGAACEK
   601  AVYVLDEPEP AIRKSYQAVE RHGETIRVRD TVLLKSGPRK TSTPYVAKIS ALWENPESGE
   661  LMMSLLWYYR PEHLQGGRSP SMHEPLQNEV FASRHQDQNS VACIEEKCYV LTFAEYCRFC
   721  AMAKRRGEGL PSRKTALVPP SADYSTPPHR TVPEDTDPEL VFLCRHVYDF RHGRILKNPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAHD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 21 nTPM
ovary: 20 nTPM
testis: 18 nTPM
thyroid gland: 16 nTPM
heart muscle: 14 nTPM
fallopian tube: 14 nTPM

Single-cell type

alveolar cells type 1: 54 nCPM
adrenal cortex cells: 45 nCPM
adrenal medulla cells: 43 nCPM
sertoli cells: 32 nCPM
alveolar cells type 2: 30 nCPM
extravillous trophoblasts: 29 nCPM

Immune cell

eosinophil: 1.4 nTPM
NK-cell: 1.4 nTPM
gdT-cell: 1.3 nTPM
naive CD4 T-cell: 1.2 nTPM
non-classical monocyte: 1.2 nTPM
naive CD8 T-cell: 1 nTPM

Brain region

hippocampal formation: 21 nTPM
cerebral cortex: 20 nTPM
hypothalamus: 19 nTPM
amygdala: 18 nTPM
medulla oblongata: 18 nTPM
basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.99
gnomAD missense Z: 1.31
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Bromo adjacent homology (BAH) domain
Bromo adjacent homology (BAH) domain superfamily
BAH domain
Bromo adjacent homology domain-containing protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BAHD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BAHD1 as an antibody target. Whether an autoantibody or antibody against BAHD1 could matter depends on whether native BAHD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BAHD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BAHD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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