Seroatlas · Human Serome Atlas

HDAC5

Histone deacetylase 5

Also known as: FLJ90614, HDAC5_HUMAN, KIAA0600, NY-CO-9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UQL6
Gene: HDAC5
Ensembl: ENSG00000108840
Chromosome: 17
Canonical length: 1122 aa
Protein class: Cancer-related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Golgi apparatus,Cytosol

OverviewNCBI Gene

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1122 residues, UniProt reviewed canonical sequence.

>Q9UQL6|HDAC5
     1  MNSPNESDGM SGREPSLEIL PRTSLHSIPV TVEVKPVLPR AMPSSMGGGG GGSPSPVELR
    61  GALVGSVDPT LREQQLQQEL LALKQQQQLQ KQLLFAEFQK QHDHLTRQHE VQLQKHLKQQ
   121  QEMLAAKQQQ EMLAAKRQQE LEQQRQREQQ RQEELEKQRL EQQLLILRNK EKSKESAIAS
   181  TEVKLRLQEF LLSKSKEPTP GGLNHSLPQH PKCWGAHHAS LDQSSPPQSG PPGTPPSYKL
   241  PLPGPYDSRD DFPLRKTASE PNLKVRSRLK QKVAERRSSP LLRRKDGTVI STFKKRAVEI
   301  TGAGPGASSV CNSAPGSGPS SPNSSHSTIA ENGFTGSVPN IPTEMLPQHR ALPLDSSPNQ
   361  FSLYTSPSLP NISLGLQATV TVTNSHLTAS PKLSTQQEAE RQALQSLRQG GTLTGKFMST
   421  SSIPGCLLGV ALEGDGSPHG HASLLQHVLL LEQARQQSTL IAVPLHGQSP LVTGERVATS
   481  MRTVGKLPRH RPLSRTQSSP LPQSPQALQQ LVMQQQHQQF LEKQKQQQLQ LGKILTKTGE
   541  LPRQPTTHPE ETEEELTEQQ EVLLGEGALT MPREGSTESE STQEDLEEED EEDDGEEEED
   601  CIQVKDEEGE SGAEEGPDLE EPGAGYKKLF SDAQPLQPLQ VYQAPLSLAT VPHQALGRTQ
   661  SSPAAPGGMK SPPDQPVKHL FTTGVVYDTF MLKHQCMCGN THVHPEHAGR IQSIWSRLQE
   721  TGLLSKCERI RGRKATLDEI QTVHSEYHTL LYGTSPLNRQ KLDSKKLLGP ISQKMYAVLP
   781  CGGIGVDSDT VWNEMHSSSA VRMAVGCLLE LAFKVAAGEL KNGFAIIRPP GHHAEESTAM
   841  GFCFFNSVAI TAKLLQQKLN VGKVLIVDWD IHHGNGTQQA FYNDPSVLYI SLHRYDNGNF
   901  FPGSGAPEEV GGGPGVGYNV NVAWTGGVDP PIGDVEYLTA FRTVVMPIAH EFSPDVVLVS
   961  AGFDAVEGHL SPLGGYSVTA RCFGHLTRQL MTLAGGRVVL ALEGGHDLTA ICDASEACVS
  1021  ALLSVELQPL DEAVLQQKPN INAVATLEKV IEIQSKHWSC VQKFAAGLGR SLREAQAGET
  1081  EEAETVSAMA LLSVGAEQAQ AAAAREHSPR PAEEPMEQEP AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDAC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 73 nTPM
skin: 67 nTPM
cerebral cortex: 60 nTPM
blood vessel: 55 nTPM
heart muscle: 47 nTPM
amygdala: 46 nTPM

Single-cell type

syncytiotrophoblasts: 363 nCPM
platelets: 154 nCPM
neutrophils: 139 nCPM
cone photoreceptor cells: 114 nCPM
retinal bipolar cells: 113 nCPM
extravillous trophoblasts: 107 nCPM

Immune cell

neutrophil: 21 nTPM
non-classical monocyte: 17 nTPM
intermediate monocyte: 13 nTPM
basophil: 12 nTPM
myeloid DC: 11 nTPM
plasmacytoid DC: 9.7 nTPM

Brain region

cerebellum: 144 nTPM
white matter: 143 nTPM
cerebral cortex: 142 nTPM
midbrain: 134 nTPM
thalamus: 129 nTPM
amygdala: 126 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 3.32
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HDAC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDAC5 as an antibody target. Whether an autoantibody or antibody against HDAC5 could matter depends on whether native HDAC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDAC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDAC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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