Seroatlas · Human Serome Atlas

ELMO1

Engulfment and cell motility protein 1

Also known as: CED-12, CED12, ELMO-1, ELMO1_HUMAN, KIAA0281

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92556
Gene: ELMO1
Ensembl: ENSG00000155849
Chromosome: 7
Canonical length: 727 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

727 residues, UniProt reviewed canonical sequence.

>Q92556|ELMO1
     1  MPPPADIVKV AIEWPGAYPK LMEIDQKKPL SAIIKEVCDG WSLANHEYFA LQHADSSNFY
    61  ITEKNRNEIK NGTILRLTTS PAQNAQQLHE RIQSSSMDAK LEALKDLASL SRDVTFAQEF
   121  INLDGISLLT QMVESGTERY QKLQKIMKPC FGDMLSFTLT AFVELMDHGI VSWDTFSVAF
   181  IKKIASFVNK SAIDISILQR SLAILESMVL NSHDLYQKVA QEITIGQLIP HLQGSDQEIQ
   241  TYTIAVINAL FLKAPDERRQ EMANILAQKQ LRSIILTHVI RAQRAINNEM AHQLYVLQVL
   301  TFNLLEDRMM TKMDPQDQAQ RDIIFELRRI AFDAESEPNN SSGSMEKRKS MYTRDYKKLG
   361  FINHVNPAMD FTQTPPGMLA LDNMLYFAKH HQDAYIRIVL ENSSREDKHE CPFGRSSIEL
   421  TKMLCEILKV GELPSETCND FHPMFFTHDR SFEEFFCICI QLLNKTWKEM RATSEDFNKV
   481  MQVVKEQVMR ALTTKPSSLD QFKSKLQNLS YTEILKIRQS ERMNQEDFQS RPILELKEKI
   541  QPEILELIKQ QRLNRLVEGT CFRKLNARRR QDKFWYCRLS PNHKVLHYGD LEESPQGEVP
   601  HDSLQDKLPV ADIKAVVTGK DCPHMKEKGA LKQNKEVLEL AFSILYDSNC QLNFIAPDKH
   661  EYCIWTDGLN ALLGKDMMSD LTRNDLDTLL SMEIKLRLLD LENIQIPDAP PPIPKEPSNY
   721  DFVYDCN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELMO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 118 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 118 nTPM
cerebral cortex: 111 nTPM
hippocampal formation: 82 nTPM
basal ganglia: 80 nTPM
midbrain: 78 nTPM
cerebellum: 77 nTPM

Single-cell type

hematopoietic stem cells: 4,535 nCPM
microglia: 1,925 nCPM
oligodendrocytes: 1,829 nCPM
megakaryocyte-erythroid progenitors: 1,806 nCPM
neutrophils: 1,759 nCPM
neutrophil progenitors: 1,278 nCPM

Immune cell

eosinophil: 165 nTPM
neutrophil: 108 nTPM
myeloid DC: 78 nTPM
total PBMC: 56 nTPM
classical monocyte: 53 nTPM
memory CD4 T-cell: 52 nTPM

Brain region

white matter: 459 nTPM
medulla oblongata: 278 nTPM
basal ganglia: 269 nTPM
thalamus: 261 nTPM
pons: 260 nTPM
cerebral cortex: 250 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.9
gnomAD missense Z: 3.13
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SH3 domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELMO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELMO1 as an antibody target. Whether an autoantibody or antibody against ELMO1 could matter depends on whether native ELMO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELMO1 is annotated at the cell surface, where native ELMO1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ELMO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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