Seroatlas · Human Serome Atlas

WDCP

WD repeat and coiled-coil-containing protein

Also known as: C2orf44, FLJ21945, MMAP, WDCP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H6R7
Gene
WDCP
Ensembl
ENSG00000163026
Chromosome
2
Canonical length
721 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

Enables kinase binding activity. Involved in protein complex oligomerization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

721 residues, UniProt reviewed canonical sequence.

>Q9H6R7|WDCP
     1  MELGKGKLLR TGLNALHQAV HPIHGLAWTD GNQVVLTDLR LHSGEVKFGD SKVIGQFECV
    61  CGLSWAPPVA DDTPVLLAVQ HEKHVTVWQL CPSPMESSKW LTSQTCEIRG SLPILPQGCV
   121  WHPKCAILTV LTAQDVSIFP NVHSDDSQVK ADINTQGRIH CACWTQDGLR LVVAVGSSLH
   181  SYIWDSAQKT LHRCSSCLVF DVDSHVCSIT ATVDSQVAIA TELPLDKICG LNASETFNIP
   241  PNSKDMTPYA LPVIGEVRSM DKEATDSETN SEVSVSSSYL EPLDLTHIHF NQHKSEGNSL
   301  ICLRKKDYLT GTGQDSSHLV LVTFKKAVTM TRKVTIPGIL VPDLIAFNLK AHVVAVASNT
   361  CNIILIYSVI PSSVPNIQQI RLENTERPKG ICFLTDQLLL ILVGKQKLTD TTFLPSSKSD
   421  QYAISLIVRE IMLEEEPSIT SGESQTTYST FSAPLNKANR KKLIESLSPD FCHQNKGLLL
   481  TVNTSSQNGR PGRTLIKEIQ SPLSSICDGS IALDAEPVTQ PASLPRHSST PDHTSTLEPP
   541  RLPQRKNLQS EKETYQLSKE VEILSRNLVE MQRCLSELTN RLHNGKKSSS VYPLSQDLPY
   601  VHIIYQKPYY LGPVVEKRAV LLCDGKLRLS TVQQTFGLSL IEMLHDSHWI LLSADSEGFI
   661  PLTFTATQEI IIRDGSLSRS DVFRDSFSHS PGAVSSLKVF TGLAAPSLDT TGCCNHVDGM
   721  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDCP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
8.1 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 8.1 nTPM
  • thymus: 7.1 nTPM
  • tonsil: 6.5 nTPM
  • lymph node: 6.2 nTPM
  • retina: 5.8 nTPM
  • skeletal muscle: 5.7 nTPM

Single-cell type

  • adrenal medulla cells: 21 nCPM
  • early primary spermatocytes: 18 nCPM
  • epicardial cells: 14 nCPM
  • myonuclei: 12 nCPM
  • cone photoreceptor cells: 10 nCPM
  • oocytes: 9.2 nCPM

Immune cell

  • MAIT T-cell: 5.4 nTPM
  • T-reg: 5.4 nTPM
  • gdT-cell: 5.2 nTPM
  • naive CD8 T-cell: 5 nTPM
  • naive CD4 T-cell: 4.6 nTPM
  • NK-cell: 3.9 nTPM

Brain region

  • cerebellum: 6.9 nTPM
  • choroid plexus: 6.7 nTPM
  • white matter: 6.5 nTPM
  • hypothalamus: 5.9 nTPM
  • midbrain: 5.7 nTPM
  • basal ganglia: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

  • WD repeat and coiled-coil-containing protein family
  • WD repeat and coiled-coil-containing protein family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDCP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDCP as an antibody target. Whether an autoantibody or antibody against WDCP could matter depends on whether native WDCP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDCP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDCP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDCP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...