Seroatlas · Human Serome Atlas

RPF2

Ribosome production factor 2 homolog

Also known as: bA397G5.4, BXDC1, FLJ21087, RPF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7B2
Gene: RPF2
Ensembl: ENSG00000197498
Chromosome: 6
Canonical length: 306 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables 5S rRNA binding activity. Involved in protein localization to nucleolus; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q9H7B2|RPF2
     1  MDTLDRVVKP KTKRAKRFLE KREPKLNENI KNAMLIKGGN ANATVTKVLK DVYALKKPYG
    61  VLYKKKNITR PFEDQTSLEF FSKKSDCSLF MFGSHNKKRP NNLVIGRMYD YHVLDMIELG
   121  IENFVSLKDI KNSKCPEGTK PMLIFAGDDF DVTEDYRRLK SLLIDFFRGP TVSNIRLAGL
   181  EYVLHFTALN GKIYFRSYKL LLKKSGCRTP RIELEEMGPS LDLVLRRTHL ASDDLYKLSM
   241  KMPKALKPKK KKNISHDTFG TTYGRIHMQK QDLSKLQTRK MKGLKKRPAE RITEDHEKKS
   301  KRIKKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 20 nTPM
liver: 16 nTPM
urinary bladder: 14 nTPM
pancreas: 14 nTPM
tongue: 13 nTPM
adipose tissue: 13 nTPM

Single-cell type

late primary spermatocytes: 193 nCPM
esophageal basal cells: 112 nCPM
erythrocyte progenitors: 109 nCPM
hepatocytes: 104 nCPM
oocytes: 101 nCPM
basal keratinocytes: 100 nCPM

Immune cell

NK-cell: 8.9 nTPM
MAIT T-cell: 8.5 nTPM
naive CD8 T-cell: 7 nTPM
naive CD4 T-cell: 6.8 nTPM
memory B-cell: 6.6 nTPM
memory CD4 T-cell: 6.1 nTPM

Brain region

white matter: 9.4 nTPM
basal ganglia: 8.8 nTPM
cerebellum: 8.4 nTPM
choroid plexus: 8.4 nTPM
thalamus: 8.4 nTPM
cerebral cortex: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.05
gnomAD missense Z: 0.54
DepMap mean gene effect: -1.29
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Brix domain
Brix domain
Ribosome biogenesis protein Rpf2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPF2 as an antibody target. Whether an autoantibody or antibody against RPF2 could matter depends on whether native RPF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...