Seroatlas · Human Serome Atlas

UTP3

Something about silencing protein 10

Also known as: CRLZ1, DKFZp761F222, FLJ23256, SAS10, SAS10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQZ2
Gene
UTP3
Ensembl
ENSG00000132467
Chromosome
4
Canonical length
479 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Vesicles

OverviewNCBI Gene

Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in nucleolus. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q9NQZ2|UTP3
     1  MVGRSRRRGA AKWAAVRAKA GPTLTDENGD DLGLPPSPGD TSYYQDQVDD FHEARSRAAL
    61  AKGWNEVQSG DEEDGEEEEE EVLALDMDDE DDEDGGNAGE EEEEENADDD GGSSVQSEAE
   121  ASVDPSLSWG QRKKLYYDTD YGSKSRGRQS QQEAEEEERE EEEEAQIIQR RLAQALQEDD
   181  FGVAWVEAFA KPVPQVDEAE TRVVKDLAKV SVKEKLKMLR KESPELLELI EDLKVKLTEV
   241  KDELEPLLEL VEQGIIPPGK GSQYLRTKYN LYLNYCSNIS FYLILKARRV PAHGHPVIER
   301  LVTYRNLINK LSVVDQKLSS EIRHLLTLKD DAVKKELIPK AKSTKPKPKS VSKTSAAACA
   361  VTDLSDDSDF DEKAKLKYYK EIEDRQKLKR KKEENSTEEQ ALEDQNAKRA ITYQIAKNRG
   421  LTPRRKKIDR NPRVKHREKF RRAKIRRRGQ VREVRKEEQR YSGELSGIRA GVKKSIKLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 34 nTPM
  • lymph node: 31 nTPM
  • thymus: 30 nTPM
  • tonsil: 30 nTPM
  • liver: 25 nTPM
  • appendix: 24 nTPM

Single-cell type

  • kupffer cells: 59 nCPM
  • esophageal suprabasal cells: 47 nCPM
  • alveolar cells type 2: 42 nCPM
  • pancreatic islet cells: 42 nCPM
  • smooth muscle cells: 41 nCPM
  • fallopian secretory cells: 40 nCPM

Immune cell

  • plasmacytoid DC: 14 nTPM
  • myeloid DC: 14 nTPM
  • intermediate monocyte: 13 nTPM
  • non-classical monocyte: 11 nTPM
  • classical monocyte: 11 nTPM
  • basophil: 8.4 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • cerebral cortex: 15 nTPM
  • hippocampal formation: 15 nTPM
  • thalamus: 15 nTPM
  • hypothalamus: 15 nTPM
  • white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
1.15
DepMap mean gene effect
-0.65
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UTP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTP3 as an antibody target. Whether an autoantibody or antibody against UTP3 could matter depends on whether native UTP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UTP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UTP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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