Seroatlas · Human Serome Atlas

BUD23

18S rRNA (guanine-N(7))-methyltransferase

Also known as: BUD23_HUMAN, MERM1, MGC19709, MGC2022, MGC5140, PP3381, WBMT, WBSCR22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43709
Gene
BUD23
Ensembl
ENSG00000071462
Chromosome
7
Canonical length
281 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>O43709|BUD23
     1  MASRGRRPEH GGPPELFYDE TEARKYVRNS RMIDIQTRMA GRALELLYLP ENKPCYLLDI
    61  GCGTGLSGSY LSDEGHYWVG LDISPAMLDE AVDREIEGDL LLGDMGQGIP FKPGTFDGCI
   121  SISAVQWLCN ANKKSENPAK RLYCFFASLF SVLVRGSRAV LQLYPENSEQ LELITTQATK
   181  AGFSGGMVVD YPNSAKAKKF YLCLFSGPST FIPEGLSENQ DEVEPRESVF TNERFPLRMS
   241  RRGMVRKSRA WVLEKKERHR RQGREVRPDT QYTGRKRKPR F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BUD23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
116 nTPM

Expression across tissuesHPA

Tissue

  • testis: 116 nTPM
  • skeletal muscle: 115 nTPM
  • heart muscle: 82 nTPM
  • tongue: 74 nTPM
  • choroid plexus: 74 nTPM
  • bone marrow: 72 nTPM

Single-cell type

  • early primary spermatocytes: 723 nCPM
  • differentiating spermatogonia: 620 nCPM
  • undifferentiated spermatogonia: 476 nCPM
  • plasma cells: 186 nCPM
  • oocytes: 175 nCPM
  • breast lactating cells: 166 nCPM

Immune cell

  • plasmacytoid DC: 186 nTPM
  • memory B-cell: 173 nTPM
  • naive B-cell: 150 nTPM
  • T-reg: 145 nTPM
  • naive CD4 T-cell: 132 nTPM
  • total PBMC: 130 nTPM

Brain region

  • choroid plexus: 46 nTPM
  • white matter: 43 nTPM
  • cerebral cortex: 42 nTPM
  • hypothalamus: 40 nTPM
  • medulla oblongata: 40 nTPM
  • thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
DepMap mean gene effect
-1.43
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BUD23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BUD23 as an antibody target. Whether an autoantibody or antibody against BUD23 could matter depends on whether native BUD23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BUD23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BUD23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BUD23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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