Seroatlas · Human Serome Atlas

MMP24

Matrix metalloproteinase-24

Also known as: MMP24_HUMAN, MT5-MMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5R2
Gene
MMP24
Ensembl
ENSG00000125966
Chromosome
20
Canonical length
645 aa
Protein class
Enzymes, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Nucleoli,Plasma membrane
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). The gene has previously been referred to as MMP25 but has been renamed matrix metallopeptidase 24 (MMP24). [provided by RefSeq, Oct 2019]

Canonical amino-acid sequenceUniProt

645 residues, UniProt reviewed canonical sequence.

>Q9Y5R2|MMP24
     1  MPRSRGGRAA PGPPPPPPPP GQAPRWSRWR VPGRLLLLLL PALCCLPGAA RAAAAAAGAG
    61  NRAAVAVAVA RADEAEAPFA GQNWLKSYGY LLPYDSRASA LHSAKALQSA VSTMQQFYGI
   121  PVTGVLDQTT IEWMKKPRCG VPDHPHLSRR RRNKRYALTG QKWRQKHITY SIHNYTPKVG
   181  ELDTRKAIRQ AFDVWQKVTP LTFEEVPYHE IKSDRKEADI MIFFASGFHG DSSPFDGEGG
   241  FLAHAYFPGP GIGGDTHFDS DEPWTLGNAN HDGNDLFLVA VHELGHALGL EHSSDPSAIM
   301  APFYQYMETH NFKLPQDDLQ GIQKIYGPPA EPLEPTRPLP TLPVRRIHSP SERKHERQPR
   361  PPRPPLGDRP STPGTKPNIC DGNFNTVALF RGEMFVFKDR WFWRLRNNRV QEGYPMQIEQ
   421  FWKGLPARID AAYERADGRF VFFKGDKYWV FKEVTVEPGY PHSLGELGSC LPREGIDTAL
   481  RWEPVGKTYF FKGERYWRYS EERRATDPGY PKPITVWKGI PQAPQGAFIS KEGYYTYFYK
   541  GRDYWKFDNQ KLSVEPGYPR NILRDWMGCN QKEVERRKER RLPQDDVDIM VTINDVPGSV
   601  NAVAVVIPCI LSLCILVLVY TIFQFKNKTG PQPVTYYKRP VQEWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMP24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 68 nTPM
  • cerebral cortex: 8.6 nTPM
  • kidney: 7.3 nTPM
  • basal ganglia: 6 nTPM
  • pancreas: 5.5 nTPM
  • hypothalamus: 5.3 nTPM

Single-cell type

  • enterocytes: 111 nCPM
  • suprabasal keratinocytes: 96 nCPM
  • brain excitatory neurons: 92 nCPM
  • epicardial cells: 86 nCPM
  • basal keratinocytes: 80 nCPM
  • cholangiocytes: 71 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • cerebellum: 89 nTPM
  • cerebral cortex: 22 nTPM
  • thalamus: 21 nTPM
  • amygdala: 18 nTPM
  • hippocampal formation: 18 nTPM
  • midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.68
gnomAD missense Z
2.28
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MMP24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMP24 as an antibody target. Whether an autoantibody or antibody against MMP24 could matter depends on whether native MMP24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMP24 is annotated at the cell surface, where native MMP24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MMP24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MMP24. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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