Seroatlas · Human Serome Atlas

EFNB1

Ephrin-B1

Also known as: CFNS, EFNB1_HUMAN, Elk-L, EPLG2, LERK2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P98172
Gene
EFNB1
Ensembl
ENSG00000090776
Chromosome
X
Canonical length
346 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>P98172|EFNB1
     1  MARPGQRWLG KWLVAMVVWA LCRLATPLAK NLEPVSWSSL NPKFLSGKGL VIYPKIGDKL
    61  DIICPRAEAG RPYEYYKLYL VRPEQAAACS TVLDPNVLVT CNRPEQEIRF TIKFQEFSPN
   121  YMGLEFKKHH DYYITSTSNG SLEGLENREG GVCRTRTMKI IMKVGQDPNA VTPEQLTTSR
   181  PSKEADNTVK MATQAPGSRG SLGDSDGKHE TVNQEEKSGP GASGGSSGDP DGFFNSKVAL
   241  FAAVGAGCVI FLLIIIFLTV LLLKLRKRHR KHTQQRAAAL SLSTLASPKG GSGTAGTEPS
   301  DIIIPLRTTE NNYCPHYEKV SGDYGHPVYI VQEMPPQSPA NIYYKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFNB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • skin: 51 nTPM
  • adipose tissue: 44 nTPM
  • kidney: 42 nTPM
  • breast: 41 nTPM
  • lung: 39 nTPM
  • heart muscle: 32 nTPM

Single-cell type

  • extravillous trophoblasts: 120 nCPM
  • basal keratinocytes: 112 nCPM
  • suprabasal keratinocytes: 89 nCPM
  • podocytes: 77 nCPM
  • esophageal basal cells: 75 nCPM
  • urothelial cells: 67 nCPM

Immune cell

  • myeloid DC: 3.5 nTPM
  • intermediate monocyte: 1.7 nTPM
  • non-classical monocyte: 1.1 nTPM
  • NK-cell: 0.7 nTPM
  • classical monocyte: 0.6 nTPM
  • plasmacytoid DC: 0.5 nTPM

Brain region

  • cerebral cortex: 8.5 nTPM
  • thalamus: 8.2 nTPM
  • spinal cord: 7.9 nTPM
  • basal ganglia: 7.7 nTPM
  • medulla oblongata: 7.6 nTPM
  • hypothalamus: 7.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EFNB1.

Disease | AllUniProt

Conditions EFNB1 is implicated in, by any mechanism.

Disease | GeneticClinVar

70 pathogenic / likely-pathogenic of 222 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.93
gnomAD missense Z
1.59
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EFNB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFNB1 as an antibody target. Whether an autoantibody or antibody against EFNB1 could matter depends on whether native EFNB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFNB1 is annotated at the cell surface, where native EFNB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EFNB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EFNB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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