Seroatlas · Human Serome Atlas

GADD45B

Growth arrest and DNA damage-inducible protein GADD45 beta

Also known as: DKFZP566B133, GA45B_HUMAN, GADD45BETA, MYD118

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75293
Gene
GADD45B
Ensembl
ENSG00000099860
Chromosome
19
Canonical length
160 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>O75293|GADD45B
     1  MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA
    61  IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL
   121  LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GADD45B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
538 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 538 nTPM
  • liver: 384 nTPM
  • heart muscle: 364 nTPM
  • adipose tissue: 328 nTPM
  • lung: 322 nTPM
  • bone marrow: 304 nTPM

Single-cell type

  • vascular smooth muscle cells: 2,537 nCPM
  • epididymal basal cells: 2,078 nCPM
  • breast myoepithelial cells: 1,950 nCPM
  • smooth muscle cells: 1,588 nCPM
  • endometrial luminal cells: 1,493 nCPM
  • breast lactating cells: 1,201 nCPM

Immune cell

  • eosinophil: 132 nTPM
  • neutrophil: 93 nTPM
  • gdT-cell: 58 nTPM
  • T-reg: 55 nTPM
  • MAIT T-cell: 52 nTPM
  • naive CD8 T-cell: 48 nTPM

Brain region

  • cerebral cortex: 69 nTPM
  • thalamus: 59 nTPM
  • hypothalamus: 56 nTPM
  • medulla oblongata: 52 nTPM
  • choroid plexus: 50 nTPM
  • spinal cord: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0.21
gnomAD missense Z
1.21
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GADD45B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GADD45B as an antibody target. Whether an autoantibody or antibody against GADD45B could matter depends on whether native GADD45B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GADD45B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GADD45B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GADD45B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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