Seroatlas · Human Serome Atlas

MRPL12

Large ribosomal subunit protein bL12m

Also known as: MRPL7, MRPL7/L12, RM12_HUMAN, RPML12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52815
Gene
MRPL12
Ensembl
ENSG00000262814
Chromosome
17
Canonical length
198 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>P52815|MRPL12
     1  MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG APLDNAPKEY
    61  PPKIQQLVQD IASLTLLEIS DLNELLKKTL KIQDVGLVPM GGVMSGAVPA AAAQEAVEED
   121  IPIAKERTHF TVRLTEAKPV DKVKLIKEIK NYIQGINLVQ AKKLVESLPQ EIKANVAKAE
   181  AEKIKAALEA VGGTVVLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
203 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 203 nTPM
  • liver: 185 nTPM
  • skeletal muscle: 168 nTPM
  • tongue: 138 nTPM
  • kidney: 97 nTPM
  • esophagus: 96 nTPM

Single-cell type

  • parietal cells: 71 nCPM
  • gastric chief cells: 33 nCPM
  • enteric transient amplifying cells: 18 nCPM
  • foveolar cells: 15 nCPM
  • colonocytes: 13 nCPM
  • enteric stem cells: 12 nCPM

Immune cell

  • myeloid DC: 94 nTPM
  • intermediate monocyte: 85 nTPM
  • plasmacytoid DC: 77 nTPM
  • memory B-cell: 67 nTPM
  • classical monocyte: 63 nTPM
  • naive B-cell: 62 nTPM

Brain region

  • choroid plexus: 65 nTPM
  • cerebellum: 57 nTPM
  • thalamus: 56 nTPM
  • midbrain: 51 nTPM
  • hypothalamus: 48 nTPM
  • pons: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRPL12.

Disease | AllUniProt

Conditions MRPL12 is implicated in, by any mechanism.

  • Combined oxidative phosphorylation deficiency 45 (COXPD45) MIM:618951

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 126 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Combined oxidative phosphorylation deficiency 45

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
-0.44
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ribosomal protein bL12, C-terminal/adaptor protein ClpS-like
  • Large ribosomal subunit protein bL12
  • Large ribosomal subunit protein bL12, oligomerization
  • Large ribosomal subunit protein bL12, C-terminal
  • Large ribosomal subunit protein bL12, oligomerization domain superfamily
  • Ribosomal protein L7/L12 C-terminal domain
  • Ribosomal protein L7/L12 dimerisation domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL12 as an antibody target. Whether an autoantibody or antibody against MRPL12 could matter depends on whether native MRPL12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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